{"id":3003,"date":"2024-08-08T11:32:31","date_gmt":"2024-08-08T01:32:31","guid":{"rendered":"https:\/\/www.cognav.net\/?p=3003"},"modified":"2024-08-08T11:32:31","modified_gmt":"2024-08-08T01:32:31","slug":"how-visual-information-becomes-encoded-by-the-brains-navigation-systems","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=3003","title":{"rendered":"How visual information becomes encoded by the brain&#8217;s navigation systems?"},"content":{"rendered":"<p style=\"text-align: justify;\">Dubanet, O. and Higley, M.J., 2024. <strong><a href=\"https:\/\/www.cell.com\/cell-reports\/fulltext\/S2211-1247(24)00799-X\">Retrosplenial inputs drive visual representations in the medial entorhinal cortex<\/a><\/strong>. Cell Reports, 43(7).<\/p>\n<p style=\"text-align: justify;\">Summary<br \/>\n\u201c<strong><span style=\"color: #ff0000;\">The importance of visual cues for navigation and goal-directed behavior is well established, although the neural mechanisms supporting sensory representations in navigational circuits are largely unknown<\/span><\/strong>. Navigation is fundamentally dependent on the medial entorhinal cortex (MEC), which receives direct projections from neocortical visual areas, including the retrosplenial cortex (RSC). Here, we perform high-density recordings of MEC neurons in awake, head-fixed mice presented with simple visual stimuli and assess the dynamics of sensory-evoked activity. We find that a large fraction of neurons exhibit robust responses to visual input. <strong><span style=\"color: #ff0000;\">Visually responsive cells are located primarily in layer 3 of the dorsal MEC and can be separated into subgroups based on functional and molecular properties<\/span><\/strong>. Furthermore, optogenetic suppression of RSC afferents within the MEC strongly reduces visual responses. Overall, our results demonstrate that <strong><span style=\"color: #ff0000;\">the MEC can encode simple visual cues in the environment that may contribute to neural representations of location necessary for accurate navigation<\/span><\/strong>.\u201d<\/p>\n<p style=\"text-align: justify;\">Dubanet, O. and Higley, M.J., 2024. <strong><a href=\"https:\/\/www.cell.com\/cell-reports\/fulltext\/S2211-1247(24)00799-X\">Retrosplenial inputs drive visual representations in the medial entorhinal cortex<\/a><\/strong>. Cell Reports, 43(7).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dubanet, O. and Higley, M.J., 2024. Retrosplenial inputs drive visual representations in the medial entorhinal cortex. Cell Reports, 43(7). Summary \u201cThe importance of visual cues for navigation and goal-directed behavior is well established, although the neural mechanisms supporting sensory representations in navigational circuits are largely unknown. Navigation is fundamentally dependent on the medial entorhinal cortex [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96,346,419,850],"tags":[1012,1320,1331],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3003"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3003"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3003\/revisions"}],"predecessor-version":[{"id":3004,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3003\/revisions\/3004"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3003"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3003"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3003"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}