{"id":3023,"date":"2024-08-19T11:27:51","date_gmt":"2024-08-19T01:27:51","guid":{"rendered":"https:\/\/www.cognav.net\/?p=3023"},"modified":"2024-08-19T11:27:51","modified_gmt":"2024-08-19T01:27:51","slug":"how-shifts-in-the-composition-of-memory-encoding-neuronal-ensembles-influence-the-evolution-of-a-memory-over-time","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=3023","title":{"rendered":"How shifts in the composition of memory-encoding neuronal ensembles influence the evolution of a memory over time?"},"content":{"rendered":"<p style=\"text-align: justify;\">Vilde A. Kveim et al. ,<a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.adk0997\"><strong>Divergent recruitment of developmentally defined neuronal ensembles supports memory dynamics<\/strong><\/a>.Science 385,eadk0997(2024).DOI:10.1126\/science.adk0997<\/p>\n<p style=\"text-align: justify;\">Editor\u2019s summary<br \/>\n&#8220;<strong><span style=\"color: #ff0000;\">Memories are not fixed; they evolve after encoding and their content can be updated upon changes in external or internal contingencies<\/span><\/strong>. Kveim et al. investigated the mechanisms that govern the reorganization of neuronal ensembles linked to a specific memory and <strong><span style=\"color: #ff0000;\">how these dynamic changes affect memory persistence over time<\/span><\/strong>. They found that in <strong><span style=\"color: #ff0000;\">the hippocampal network, learning resulted in the parallel establishment of two distinct memory traces<\/span><\/strong>. These traces were represented in distinct neurogenesis-defined subpopulations of early- and late-born neurons. Even though temporally restricted, the transient recruitment of late-born neurons was necessary for a memory\u2019s long-term permanence, whereas shifts in the recruitment of early- and late-born neurons had a strong impact on the plasticity of a recently acquired memory.&#8221; \u2014Peter Stern<\/p>\n<p style=\"text-align: justify;\">\nAbstract<br \/>\n&#8220;<strong><span style=\"color: #ff0000;\">Memories are dynamic constructs whose properties change with time and experience<\/span><\/strong>. The biological mechanisms underpinning these dynamics remain elusive, particularly concerning <strong><span style=\"color: #ff0000;\">how shifts in the composition of memory-encoding neuronal ensembles influence the evolution of a memory over time<\/span><\/strong>. By targeting developmentally distinct subpopulations of principal neurons, <strong><span style=\"color: #ff0000;\">we discovered that memory encoding resulted in the concurrent establishment of multiple memory traces in the mouse hippocampus<\/span><\/strong>. Two of these traces were instantiated in subpopulations of early- and late-born neurons and followed distinct reactivation trajectories after encoding. The divergent recruitment of these subpopulations underpinned gradual reorganization of memory ensembles and modulated memory persistence and plasticity across multiple learning episodes. Thus, <strong><span style=\"color: #ff0000;\">our findings reveal profound and intricate relationships between ensemble dynamics and the progression of memories over time<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Vilde A. Kveim et al. ,<a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.adk0997\"><strong>Divergent recruitment of developmentally defined neuronal ensembles supports memory dynamics<\/strong><\/a>.Science 385,eadk0997(2024).DOI:10.1126\/science.adk0997<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Vilde A. Kveim et al. ,Divergent recruitment of developmentally defined neuronal ensembles supports memory dynamics.Science 385,eadk0997(2024).DOI:10.1126\/science.adk0997 Editor\u2019s summary &#8220;Memories are not fixed; they evolve after encoding and their content can be updated upon changes in external or internal contingencies. Kveim et al. investigated the mechanisms that govern the reorganization of neuronal ensembles linked to a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[987,636,519],"tags":[1348,1349,237],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3023"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3023"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3023\/revisions"}],"predecessor-version":[{"id":3024,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3023\/revisions\/3024"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3023"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3023"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3023"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}