{"id":3040,"date":"2024-09-09T10:33:40","date_gmt":"2024-09-09T00:33:40","guid":{"rendered":"https:\/\/braininspirednavigation.com\/?p=3040"},"modified":"2024-09-09T10:33:40","modified_gmt":"2024-09-09T00:33:40","slug":"how-hippocampal-neuronal-activity-is-aligned-with-action-plans","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=3040","title":{"rendered":"How hippocampal neuronal activity is aligned with action plans?"},"content":{"rendered":"<p style=\"text-align: justify;\">Ipshita Zutshi, Athina Apostolelli, Wannan Yang, Zheyang Zheng, Tora Dohi, Edoardo Balzani, Alex Williams, Cristina Savin, Gyorgy Buzsaki. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2024.09.05.611533v1\"><strong>Hippocampal neuronal activity is aligned with action plans<\/strong><\/a>. <span class=\"highwire-cite-metadata-journal highwire-cite-metadata\">bioRxiv\u00a0<\/span><span class=\"highwire-cite-metadata-pages highwire-cite-metadata\">2024.09.05.611533;\u00a0<\/span><span class=\"highwire-cite-metadata-doi highwire-cite-metadata\"><span class=\"doi_label\">doi:<\/span>\u00a0https:\/\/doi.org\/10.1101\/2024.09.05.611533<\/span><\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;<strong><span style=\"color: #ff0000;\">Neurons in the hippocampus are correlated with different variables, including space, time, sensory cues, rewards, and actions, where the extent of tuning depends on ongoing task demands<\/span><\/strong>. However, it remains uncertain <strong><span style=\"color: #ff0000;\">whether such diverse tuning corresponds to distinct functions within the hippocampal network or if a more generic computation can account for these observations<\/span><\/strong>. To disentangle the contribution of externally driven cues versus internal computation, we developed a task in mice where space, auditory tones, rewards, and context were juxtaposed with changing relevance. High-density electrophysiological recordings revealed that neurons were tuned to each of these modalities. By comparing movement paths and action sequences, <strong><span style=\"color: #ff0000;\">we observed that external variables had limited direct influence on hippocampal firing<\/span><\/strong>. Instead, <strong><span style=\"color: #ff0000;\">spiking was influenced by online action plans modulated by goal uncertainty<\/span><\/strong>. Our results suggest that internally generated cell assembly sequences are selected and updated by action plans toward deliberate goals. <strong><span style=\"color: #ff0000;\">The apparent tuning of hippocampal neuronal spiking to different sensory modalities might emerge due to alignment to the afforded action progression within a task rather than representation of external cues<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Ipshita Zutshi, Athina Apostolelli, Wannan Yang, Zheyang Zheng, Tora Dohi, Edoardo Balzani, Alex Williams, Cristina Savin, Gyorgy Buzsaki. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2024.09.05.611533v1\"><strong>Hippocampal neuronal activity is aligned with action plans<\/strong><\/a>. <span class=\"highwire-cite-metadata-journal highwire-cite-metadata\">bioRxiv\u00a0<\/span><span class=\"highwire-cite-metadata-pages highwire-cite-metadata\">2024.09.05.611533;\u00a0<\/span><span class=\"highwire-cite-metadata-doi highwire-cite-metadata\"><span class=\"doi_label\">doi:<\/span>\u00a0https:\/\/doi.org\/10.1101\/2024.09.05.611533<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ipshita Zutshi, Athina Apostolelli, Wannan Yang, Zheyang Zheng, Tora Dohi, Edoardo Balzani, Alex Williams, Cristina Savin, Gyorgy Buzsaki. Hippocampal neuronal activity is aligned with action plans. bioRxiv\u00a02024.09.05.611533;\u00a0doi:\u00a0https:\/\/doi.org\/10.1101\/2024.09.05.611533 Abstract &#8220;Neurons in the hippocampus are correlated with different variables, including space, time, sensory cues, rewards, and actions, where the extent of tuning depends on ongoing task demands. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96,346],"tags":[1324,258,1356,1353,1354,1355],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3040"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3040"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3040\/revisions"}],"predecessor-version":[{"id":3041,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3040\/revisions\/3041"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3040"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3040"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3040"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}