{"id":3048,"date":"2024-10-28T11:06:16","date_gmt":"2024-10-28T01:06:16","guid":{"rendered":"https:\/\/braininspirednavigation.com\/?p=3048"},"modified":"2024-10-28T11:06:16","modified_gmt":"2024-10-28T01:06:16","slug":"what-are-the-mechanisms-of-memory-supporting-neuronal-dynamics-in-hippocampal-area-ca3","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=3048","title":{"rendered":"What are the mechanisms of memory-supporting neuronal dynamics in hippocampal area CA3?"},"content":{"rendered":"<p style=\"text-align: justify;\">Li, Yiding, John J. Briguglio, Sandro Romani, Jeffrey C. Magee, Eddy Kinganda-Lusamaki, Adrienne Amuri-Aziza, Nicolas Fernandez-Nu\u00f1ez et al. &#8220;<a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674%2824%2901141-3\"><strong>Mechanisms of memory-supporting neuronal dynamics in hippocampal area CA3<\/strong><\/a>.&#8221; Cell 187 (2024): 2030-2051.<\/p>\n<p style=\"text-align: justify;\">\u00a0<\/p>\n<p style=\"text-align: justify;\"><strong>Summary<\/strong><br \/>\n&#8220;<strong><span style=\"color: #ff0000;\">Hippocampal CA3 is central to memory formation and retrieval<\/span><\/strong>. Although various network mechanisms have been proposed, direct evidence is lacking. Using intracellular Vm recordings and optogenetic manipulations in behaving mice, <strong><span style=\"color: #ff0000;\">we found that CA3 place-field activity is produced by a symmetric form of behavioral timescale synaptic plasticity (BTSP) at recurrent synapses among CA3 pyramidal neurons but not at synapses from the dentate gyrus (DG)<\/span><\/strong>. Additional manipulations revealed that excitatory input from the entorhinal cortex (EC) but not the DG was required to update place cell activity based on the animal\u2019s movement. <strong><span style=\"color: #ff0000;\">These data were captured by a computational model that used BTSP and an external updating input to produce attractor dynamics under online learning conditions.<\/span><\/strong> Theoretical analyses further highlight <strong><span style=\"color: #ff0000;\">the superior memory storage capacity of such networks<\/span><\/strong>, especially when dealing with correlated input patterns. <strong><span style=\"color: #ff0000;\">This evidence elucidates the cellular and circuit mechanisms of learning and memory formation in the hippocampus<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">\u00a0<\/p>\n<p style=\"text-align: justify;\"><strong>Highlights<\/strong><br \/>\n&#8220;<\/p>\n<p style=\"text-align: justify;\">\u2022CA3 intracellular Vm recordings and optogenetic manipulations in behaving mice<br \/>\n\u2022Symmetric BTSP at CA3-CA3 recurrent synapses builds attractor dynamics within CA3<br \/>\n\u2022External EC inputs update the CA3 attractor dynamics in accordance with behavior<br \/>\n\u2022A neuronal network built by BTSP possesses superior memory storage capacity<\/p>\n<p style=\"text-align: justify;\">&#8220;<\/p>\n<p style=\"text-align: justify;\">Li, Yiding, John J. Briguglio, Sandro Romani, Jeffrey C. Magee, Eddy Kinganda-Lusamaki, Adrienne Amuri-Aziza, Nicolas Fernandez-Nu\u00f1ez et al. &#8220;<a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674%2824%2901141-3\"><strong>Mechanisms of memory-supporting neuronal dynamics in hippocampal area CA3<\/strong><\/a>.&#8221; Cell 187 (2024): 2030-2051.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Li, Yiding, John J. Briguglio, Sandro Romani, Jeffrey C. Magee, Eddy Kinganda-Lusamaki, Adrienne Amuri-Aziza, Nicolas Fernandez-Nu\u00f1ez et al. &#8220;Mechanisms of memory-supporting neuronal dynamics in hippocampal area CA3.&#8221; Cell 187 (2024): 2030-2051. \u00a0 Summary &#8220;Hippocampal CA3 is central to memory formation and retrieval. Although various network mechanisms have been proposed, direct evidence is lacking. Using intracellular [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[987,346,519],"tags":[1194,558,258,704,148,1364],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3048"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3048"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3048\/revisions"}],"predecessor-version":[{"id":3049,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3048\/revisions\/3049"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3048"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3048"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3048"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}