{"id":3050,"date":"2024-10-29T10:37:31","date_gmt":"2024-10-29T00:37:31","guid":{"rendered":"https:\/\/braininspirednavigation.com\/?p=3050"},"modified":"2024-10-29T10:37:31","modified_gmt":"2024-10-29T00:37:31","slug":"where-visual-objects-are-encoded-in-the-mouse-brain-or-how-visual-objects-impact-processing-within-the-spatial-navigation-system","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=3050","title":{"rendered":"Where visual objects are encoded in the mouse brain or how visual objects impact processing within the spatial navigation system?"},"content":{"rendered":"<p style=\"text-align: justify;\">Dominique Siegenthaler, Henry Denny, Sof\u00eda Skromne Carrasco, Johanna Luise Mayer, Adrien Peyrache, Stuart Trenholm, \u00c9milie Mac\u00e9. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2024.10.21.619417v1\"><strong>Visual objects refine head direction coding<\/strong><\/a>. bioRxiv 2024.10.21.619417; doi: https:\/\/doi.org\/10.1101\/2024.10.21.619417<\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;<strong><span style=\"color: #ff0000;\">Animals use visual objects to guide navigation-related behaviors, from hunting prey, to escaping predators, to exploring the world.<\/span><\/strong> However, <strong><span style=\"color: #ff0000;\">little is known about where visual objects are encoded in the mouse brain or how visual objects impact processing within the spatial navigation system<\/span><\/strong>. Using functional ultrasound (fUS) imaging in mice, we conducted a brain-wide screen and identified brain areas that were preferentially activated by images of objects compared to scrambled versions of the same stimuli. While visual cortical areas did not show a significant preference, regions associated with spatial navigation were preferentially activated by visual objects. Electrophysiological recordings in the postsubiculum, <strong><span style=\"color: #ff0000;\">the primary cortical area of the head direction (HD) system, further confirmed a preference for visual objects, which was present in both HD cells and fast-spiking interneurons<\/span><\/strong>. Finally, <strong><span style=\"color: #ff0000;\">we found that visual objects dynamically modulate HD cells, selectively increasing firing rates for HD cells aligned with a visual landmark&#8217;s direction<\/span><\/strong>, while suppressing activity in HD cells coding for other directions. These results reveal that <strong><span style=\"color: #ff0000;\">visual objects refine population-level coding of head direction<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Dominique Siegenthaler, Henry Denny, Sof\u00eda Skromne Carrasco, Johanna Luise Mayer, Adrien Peyrache, Stuart Trenholm, \u00c9milie Mac\u00e9. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2024.10.21.619417v1\"><strong>Visual objects refine head direction coding<\/strong><\/a>. bioRxiv 2024.10.21.619417; doi: https:\/\/doi.org\/10.1101\/2024.10.21.619417<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dominique Siegenthaler, Henry Denny, Sof\u00eda Skromne Carrasco, Johanna Luise Mayer, Adrien Peyrache, Stuart Trenholm, \u00c9milie Mac\u00e9. Visual objects refine head direction coding. bioRxiv 2024.10.21.619417; doi: https:\/\/doi.org\/10.1101\/2024.10.21.619417 Abstract &#8220;Animals use visual objects to guide navigation-related behaviors, from hunting prey, to escaping predators, to exploring the world. However, little is known about where visual objects are encoded [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96,346],"tags":[1365,1367,1366,806],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3050"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3050"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3050\/revisions"}],"predecessor-version":[{"id":3051,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3050\/revisions\/3051"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3050"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3050"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3050"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}