{"id":3071,"date":"2024-11-11T13:48:25","date_gmt":"2024-11-11T03:48:25","guid":{"rendered":"https:\/\/braininspirednavigation.com\/?p=3071"},"modified":"2024-11-11T13:48:25","modified_gmt":"2024-11-11T03:48:25","slug":"how-grid-cell-firing-patterns-rapidly-adapt-to-novel-or-changing-environmental-features-on-a-timescale-relevant-to-behaviour","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=3071","title":{"rendered":"How grid cell firing patterns rapidly adapt to novel or changing environmental features on a timescale relevant to behaviour?"},"content":{"rendered":"<p style=\"text-align: justify;\">Wen, J.H., Sorscher, B., Aery Jones, E.A. et al. <strong><a href=\"https:\/\/www.nature.com\/articles\/s41586-024-08034-3\">One-shot entorhinal maps enable flexible navigation in novel environments<\/a><\/strong>. Nature (2024). https:\/\/doi.org\/10.1038\/s41586-024-08034-3<\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;<span style=\"color: #ff0000;\"><strong>Animals must navigate changing environments to find food, shelter or mates.<\/strong><\/span> In mammals, grid cells in the medial entorhinal cortex construct a neural spatial map of the external environment1,2,3,4,5. However, <strong><span style=\"color: #ff0000;\">how grid cell firing patterns rapidly adapt to novel or changing environmental features on a timescale relevant to behaviour remains unknown<\/span><\/strong>. Here, by recording over 15,000 grid cells in mice navigating virtual environments, we tracked the real-time state of the grid cell network. This allowed us to observe and predict <strong><span style=\"color: #ff0000;\">how altering environmental features influenced grid cell firing patterns on a nearly instantaneous timescale<\/span><\/strong>. We found evidence that <strong><span style=\"color: #ff0000;\">visual landmarks provide inputs to fixed points in the grid cell network<\/span><\/strong>. This resulted in stable grid cell firing patterns in novel and altered environments after a single exposure. Fixed visual landmark inputs also influenced the grid cell network such that altering landmarks induced distortions in grid cell firing patterns. Such distortions could be predicted by a computational model with a fixed landmark to grid cell network architecture. Finally, a medial entorhinal cortex-dependent task revealed that although grid cell firing patterns are distorted by landmark changes, behaviour can adapt via a downstream region implementing behavioural timescale synaptic plasticity6. Overall, <strong><span style=\"color: #ff0000;\">our findings reveal how the navigational system of the brain constructs spatial maps that balance rapidity and accuracy<\/span><\/strong>. <strong><span style=\"color: #ff0000;\">Fixed connections between landmarks and grid cells enable the brain to quickly generate stable spatial maps, essential for navigation in novel or changing environments<\/span><\/strong>. Conversely, plasticity in regions downstream from grid cells allows the spatial maps of the brain to more accurately mirror the external spatial environment. More generally, these findings raise the possibility of a broader neural principle: <strong><span style=\"color: #ff0000;\">by allocating fixed and plastic connectivity across different networks, the brain can solve problems requiring both rapidity and representational accuracy<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Wen, J.H., Sorscher, B., Aery Jones, E.A. et al. <strong><a href=\"https:\/\/www.nature.com\/articles\/s41586-024-08034-3\">One-shot entorhinal maps enable flexible navigation in novel environments<\/a><\/strong>. Nature (2024). https:\/\/doi.org\/10.1038\/s41586-024-08034-3<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Wen, J.H., Sorscher, B., Aery Jones, E.A. et al. One-shot entorhinal maps enable flexible navigation in novel environments. Nature (2024). https:\/\/doi.org\/10.1038\/s41586-024-08034-3 Abstract &#8220;Animals must navigate changing environments to find food, shelter or mates. In mammals, grid cells in the medial entorhinal cortex construct a neural spatial map of the external environment1,2,3,4,5. However, how grid cell [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[346],"tags":[1336,1375,1374],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3071"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3071"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3071\/revisions"}],"predecessor-version":[{"id":3072,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3071\/revisions\/3072"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3071"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3071"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3071"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}