{"id":3076,"date":"2024-12-14T11:12:43","date_gmt":"2024-12-14T01:12:43","guid":{"rendered":"https:\/\/braininspirednavigation.com\/?p=3076"},"modified":"2024-12-14T11:12:43","modified_gmt":"2024-12-14T01:12:43","slug":"how-are-associative-memories-formed-which-cells-represent-a-memory-and-when-are-they-engaged","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=3076","title":{"rendered":"How are associative memories formed? Which cells represent a memory, and when are they engaged?"},"content":{"rendered":"<p style=\"text-align: justify;\">Cl\u00e9ment Pouget, Flora Morier, Nadja Treiber, Pablo Fern\u00e1ndez Garc\u00eda, Nina Mazza, Run Zhang, Isaiah Reeves, Stephen Winston, Mark A. Brimble, Christina K. Kim, Gisella Vetere. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2024.12.11.627894v1\"><strong>Deconstruction of a memory engram reveals distinct ensembles recruited at learning<\/strong><\/a>. bioRxiv 2024.12.11.627894; doi: https:\/\/doi.org\/10.1101\/2024.12.11.627894<\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n\u201c<strong><span style=\"color: #ff0000;\">How are associative memories formed? Which cells represent a memory, and when are they engaged?<\/span><\/strong> By visualizing and tagging cells based on their calcium influx with unparalleled temporal precision, <strong><span style=\"color: #ff0000;\">we identified non-overlapping dorsal CA1 neuronal ensembles that are differentially active during associative fear memory acquisition<\/span><\/strong>. We dissected the acquisition experience into periods during which salient stimuli were presented or certain mouse behaviors occurred and found that cells associated with specific acquisition periods are sufficient alone to drive memory expression and contribute to fear engram formation. This study delineated the different identities of the cell ensembles active during learning, and revealed, for the first time, which ones form the core engram and are essential for memory formation and recall.\u201d<\/p>\n<p style=\"text-align: justify;\">Cl\u00e9ment Pouget, Flora Morier, Nadja Treiber, Pablo Fern\u00e1ndez Garc\u00eda, Nina Mazza, Run Zhang, Isaiah Reeves, Stephen Winston, Mark A. Brimble, Christina K. Kim, Gisella Vetere. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2024.12.11.627894v1\"><strong>Deconstruction of a memory engram reveals distinct ensembles recruited at learning<\/strong><\/a>. bioRxiv 2024.12.11.627894; doi: https:\/\/doi.org\/10.1101\/2024.12.11.627894<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cl\u00e9ment Pouget, Flora Morier, Nadja Treiber, Pablo Fern\u00e1ndez Garc\u00eda, Nina Mazza, Run Zhang, Isaiah Reeves, Stephen Winston, Mark A. Brimble, Christina K. Kim, Gisella Vetere. Deconstruction of a memory engram reveals distinct ensembles recruited at learning. bioRxiv 2024.12.11.627894; doi: https:\/\/doi.org\/10.1101\/2024.12.11.627894 Abstract \u201cHow are associative memories formed? Which cells represent a memory, and when are they [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[636,519],"tags":[704,148,1376],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3076"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3076"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3076\/revisions"}],"predecessor-version":[{"id":3077,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3076\/revisions\/3077"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3076"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3076"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3076"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}