{"id":3155,"date":"2025-01-16T22:23:14","date_gmt":"2025-01-16T12:23:14","guid":{"rendered":"https:\/\/braininspirednavigation.com\/?p=3155"},"modified":"2025-01-16T22:23:14","modified_gmt":"2025-01-16T12:23:14","slug":"how-does-one-brain-circuit-encode-memories-of-both-places-and-events","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=3155","title":{"rendered":"How does one brain circuit encode memories of both places and events?"},"content":{"rendered":"<p style=\"text-align: justify;\">Sarthak Chandra, Sugandha Sharma, Rishidev Chaudhuri &amp; Ila Fiete. <a href=\"https:\/\/www.nature.com\/articles\/s41586-024-08392-y\"><strong>Episodic and associative memory from spatial scaffolds in the hippocampus<\/strong><\/a>. Nature (2025). https:\/\/doi.org\/10.1038\/s41586-024-08392-y<\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;Hippocampal circuits in the brain enable two distinct cognitive functions: <span style=\"color: #ff0000;\"><strong>the construction of spatial maps for navigation, and the storage of sequential episodic memories<\/strong><\/span>1,2,3,4,5. Although there have been advances in modelling spatial representations in the hippocampus6,7,8,9,10, we lack good models of its role in episodic memory. Here<strong><span style=\"color: #ff0000;\"> we present a neocortical\u2013entorhinal\u2013hippocampal network model that implements a high-capacity general associative memory, spatial memory and episodic memory.<\/span><\/strong> By factoring content storage from the dynamics of generating error-correcting stable states, the circuit (which we call vector hippocampal scaffolded heteroassociative memory (Vector-HaSH)) avoids the memory cliff of prior memory models11,12, and instead exhibits a graceful trade-off between number of stored items and recall detail. A pre-structured internal scaffold based on grid cell states is essential for constructing even non-spatial episodic memory: it enables high-capacity sequence memorization by abstracting the chaining problem into one of learning low-dimensional transitions. <strong><span style=\"color: #ff0000;\">Vector-HaSH reproduces several hippocampal experiments on spatial mapping and context-based representations, and provides a circuit model of the \u2018memory palaces\u2019 used by memory athletes<\/span><\/strong>13. Thus, this work provides a <strong><span style=\"color: #ff0000;\">unified understanding of the spatial mapping and associative and episodic memory roles of the hippocampus<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Sarthak Chandra, Sugandha Sharma, Rishidev Chaudhuri &amp; Ila Fiete. <a href=\"https:\/\/www.nature.com\/articles\/s41586-024-08392-y\"><strong>Episodic and associative memory from spatial scaffolds in the hippocampus<\/strong><\/a>. Nature (2025). https:\/\/doi.org\/10.1038\/s41586-024-08392-y<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Sarthak Chandra, Sugandha Sharma, Rishidev Chaudhuri &amp; Ila Fiete. Episodic and associative memory from spatial scaffolds in the hippocampus. Nature (2025). https:\/\/doi.org\/10.1038\/s41586-024-08392-y Abstract &#8220;Hippocampal circuits in the brain enable two distinct cognitive functions: the construction of spatial maps for navigation, and the storage of sequential episodic memories1,2,3,4,5. Although there have been advances in modelling spatial [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96,636,346,519],"tags":[349,148,1395,1396],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3155"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3155"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3155\/revisions"}],"predecessor-version":[{"id":3156,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3155\/revisions\/3156"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3155"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3155"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3155"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}