{"id":3172,"date":"2025-02-20T12:06:14","date_gmt":"2025-02-20T02:06:14","guid":{"rendered":"https:\/\/braininspirednavigation.com\/?p=3172"},"modified":"2025-02-20T12:06:46","modified_gmt":"2025-02-20T02:06:46","slug":"how-grid-cell-modules-could-emerge-from-local-interaction","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=3172","title":{"rendered":"How grid cell modules could emerge from local interaction?"},"content":{"rendered":"<p style=\"text-align: justify;\">Khona, M., Chandra, S. &amp; Fiete, I. <strong><a href=\"https:\/\/www.nature.com\/articles\/s41586-024-08541-3\">Global modules robustly emerge from local interactions and smooth gradients<\/a><\/strong>.\u00a0<i>Nature<\/i>\u00a0(2025). https:\/\/doi.org\/10.1038\/s41586-024-08541-3<\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;Modular structure and function are ubiquitous in biology, from the organization of animal brains and bodies to the scale of ecosystems. However,<strong><span style=\"color: #ff0000;\"> the mechanisms of modularity emergence from non-modular precursors remain unclear<\/span><\/strong>. Here we <strong><span style=\"color: #ff0000;\">introduce the principle of peak selection, a process by which purely local interactions and smooth gradients can drive the self-organization of discrete global modules<\/span><\/strong>. The process combines strengths of the positional and Turing pattern-formation mechanisms into a model for morphogenesis. <strong><span style=\"color: #ff0000;\">Applied to the grid-cell system of the brain, peak selection results in the self-organization of functionally distinct modules with discretely spaced spatial periods<\/span><\/strong>. Applied to ecological systems, it results in discrete multispecies niches and synchronous spawning across geographically distributed coral colonies. The process exhibits self-scaling with system size and \u2018topological robustness\u20191, which renders module emergence and module properties insensitive to most parameters. <strong><span style=\"color: #ff0000;\">Peak selection ameliorates the fine-tuning requirement for continuous attractor dynamics in single grid-cell modules<\/span> <\/strong>and it makes a detail-independent prediction that grid module period ratios should approximate adjacent integer ratios, providing a highly accurate match to the available data. Predictions for grid cells at the transcriptional, connectomic and physiological levels promise to elucidate <strong><span style=\"color: #ff0000;\">the interplay of molecules, connectivity and function emergence in brains<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Khona, M., Chandra, S. &amp; Fiete, I. <a href=\"https:\/\/www.nature.com\/articles\/s41586-024-08541-3\">Global modules robustly emerge from local interactions and smooth gradients<\/a>.\u00a0<i>Nature<\/i>\u00a0(2025). https:\/\/doi.org\/10.1038\/s41586-024-08541-3<\/p>\n<p>For further info. <a href=\"https:\/\/mcgovern.mit.edu\/2025\/02\/19\/how-nature-organizes-itself-from-brain-cells-to-ecosystems\/\">https:\/\/mcgovern.mit.edu\/2025\/02\/19\/how-nature-organizes-itself-from-brain-cells-to-ecosystems\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Khona, M., Chandra, S. &amp; Fiete, I. Global modules robustly emerge from local interactions and smooth gradients.\u00a0Nature\u00a0(2025). https:\/\/doi.org\/10.1038\/s41586-024-08541-3 Abstract &#8220;Modular structure and function are ubiquitous in biology, from the organization of animal brains and bodies to the scale of ecosystems. However, the mechanisms of modularity emergence from non-modular precursors remain unclear. Here we introduce the [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[987,346],"tags":[1417,103,1418],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3172"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3172"}],"version-history":[{"count":2,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3172\/revisions"}],"predecessor-version":[{"id":3174,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3172\/revisions\/3174"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3172"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3172"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3172"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}