{"id":3187,"date":"2025-03-22T19:32:00","date_gmt":"2025-03-22T09:32:00","guid":{"rendered":"https:\/\/braininspirednavigation.com\/?p=3187"},"modified":"2025-03-22T19:32:00","modified_gmt":"2025-03-22T09:32:00","slug":"how-spatial-coding-support-auditory-conceptual-navigation-in-the-entorhinal-hippocampal-system","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=3187","title":{"rendered":"How spatial coding support auditory conceptual navigation in the entorhinal-hippocampal system?"},"content":{"rendered":"<p style=\"text-align: justify;\">Kyle Jasmin, Max Bullock, Frederic Dick, Roger Atkins, Roberto Bottini, Federica Sigismondi, Adam Tierney. <a href=\"https:\/\/doi.org\/10.1101\/2025.02.04.636440\"><strong>Spatial coding supports auditory conceptual navigation<\/strong><\/a>. bioRxiv 2025.02.04.636440; doi: https:\/\/doi.org\/10.1101\/2025.02.04.636440<\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;<strong><span style=\"color: #ff0000;\">Grid cells in human entorhinal cortex encode spatial layouts for real-world navigation, yet their role in conceptual navigation remains unclear<\/span><\/strong>. Here <strong><span style=\"color: #ff0000;\">we show that mentally transforming tones within a purely auditory pitch-duration space engages spatial circuits, and that such resources are causally necessary<\/span><\/strong>. In Experiment 1, participants trained for five days to navigate through a purely conceptual pitch-duration auditory space, then underwent fMRI on Day 6. We observed a six-fold modulation of entorhinal BOLD signals aligned to each participant\u2019s trajectory angles, similar to grid-cell firing in physical space. Stronger grid-like coding predicted larger training-related gains. In Experiment 2, a new cohort performed the same task under either a spatial or non-spatial interference load. Only the spatial condition selectively disrupted performance on trials requiring mental \u201cmovement,\u201d indicating a causal reliance on spatial resources. <strong><span style=\"color: #ff0000;\">These findings provide evidence that auditory conceptual transformations recruit\u2014and depend on\u2014spatial grid-like computations in the entorhinal-hippocampal system, pointing to a domain-general role for spatial coding in organizing new knowledge along continuous dimensions<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Kyle Jasmin, Max Bullock, Frederic Dick, Roger Atkins, Roberto Bottini, Federica Sigismondi, Adam Tierney. <a href=\"https:\/\/doi.org\/10.1101\/2025.02.04.636440\"><strong>Spatial coding supports auditory conceptual navigation<\/strong><\/a>. bioRxiv 2025.02.04.636440; doi: https:\/\/doi.org\/10.1101\/2025.02.04.636440<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Kyle Jasmin, Max Bullock, Frederic Dick, Roger Atkins, Roberto Bottini, Federica Sigismondi, Adam Tierney. Spatial coding supports auditory conceptual navigation. bioRxiv 2025.02.04.636440; doi: https:\/\/doi.org\/10.1101\/2025.02.04.636440 Abstract &#8220;Grid cells in human entorhinal cortex encode spatial layouts for real-world navigation, yet their role in conceptual navigation remains unclear. Here we show that mentally transforming tones within a purely [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[987,96,346],"tags":[1436,1437,103,1162],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3187"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3187"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3187\/revisions"}],"predecessor-version":[{"id":3188,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3187\/revisions\/3188"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3187"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3187"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3187"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}