{"id":3204,"date":"2025-04-21T18:57:31","date_gmt":"2025-04-21T08:57:31","guid":{"rendered":"https:\/\/braininspirednavigation.com\/?p=3204"},"modified":"2025-04-21T18:57:31","modified_gmt":"2025-04-21T08:57:31","slug":"whether-stereo-olfaction-can-enable-the-formation-of-allocentric-spatial-representations","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=3204","title":{"rendered":"Whether stereo olfaction can enable the formation of allocentric spatial representations?"},"content":{"rendered":"<p style=\"text-align: justify;\">Asumbisa, K., Peyrache, A. &amp; Trenholm, S. <a href=\"https:\/\/www.nature.com\/articles\/s41467-025-58847-7\">Stereo olfaction underlies stable coding of head direction in blind mice<\/a>. Nat Commun 16, 3545 (2025). https:\/\/doi.org\/10.1038\/s41467-025-58847-7<\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;<span style=\"color: #ff0000;\">Stereo olfaction, the difference in odor concentration between the two nostrils, has been shown to affect a variety of animal behaviors, including olfactory search<\/span>. However, <strong><span style=\"color: #ff0000;\">it is unknown whether stereo olfaction can enable the formation of allocentric spatial representations<\/span><\/strong>. Here, recording from head direction (HD) cells in the anterior dorsal nucleus of the thalamus in blind mice\u2014a model system for studying olfaction-dependent allocentric spatial representations\u2014<strong><span style=\"color: #ff0000;\">we find that inhibiting stereo olfaction, by blocking olfactory processing in one nostril or merging the airflow going to both nostrils, drastically impairs head direction coding<\/span><\/strong>. To assess the behavioral impact of impaired HD cell tuning caused by loss of stereo olfaction, we developed a closed-loop head direction preference assay, in which a mouse received medial forebrain bundle reward stimulation upon orientating its head in a specific direction. <strong><span style=\"color: #ff0000;\">We find that inhibiting stereo olfaction significantly impairs performance in the HD preference assay<\/span><\/strong>. These results reveal that <strong><span style=\"color: #ff0000;\">stereo olfaction is required for mice to use smell to form a stable allocentric spatial representation of head direction<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Asumbisa, K., Peyrache, A. &amp; Trenholm, S. <a href=\"https:\/\/www.nature.com\/articles\/s41467-025-58847-7\">Stereo olfaction underlies stable coding of head direction in blind mice<\/a>. Nat Commun 16, 3545 (2025). https:\/\/doi.org\/10.1038\/s41467-025-58847-7<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Asumbisa, K., Peyrache, A. &amp; Trenholm, S. Stereo olfaction underlies stable coding of head direction in blind mice. Nat Commun 16, 3545 (2025). https:\/\/doi.org\/10.1038\/s41467-025-58847-7 Abstract &#8220;Stereo olfaction, the difference in odor concentration between the two nostrils, has been shown to affect a variety of animal behaviors, including olfactory search. However, it is unknown whether stereo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[346,419],"tags":[1452,844,253,839],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3204"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3204"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3204\/revisions"}],"predecessor-version":[{"id":3205,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3204\/revisions\/3205"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3204"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3204"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3204"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}