{"id":3213,"date":"2025-06-06T12:18:27","date_gmt":"2025-06-06T02:18:27","guid":{"rendered":"https:\/\/braininspirednavigation.com\/?p=3213"},"modified":"2025-06-06T12:18:27","modified_gmt":"2025-06-06T02:18:27","slug":"how-brain-networks-connected-by-labile-synapses-store-new-information-without-catastrophically-overwriting-previous-memories","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=3213","title":{"rendered":"How brain networks connected by labile synapses store new information without catastrophically overwriting previous memories?"},"content":{"rendered":"<p style=\"text-align: justify;\">Sachin P. Vaidya, Guanchun Li, Raymond A. Chitwood, Yiding Li &amp; Jeffrey C. Magee. <a href=\"https:\/\/www.nature.com\/articles\/s41593-025-01986-3\"><strong>Formation of an expanding memory representation in the hippocampus<\/strong><\/a>. Nat Neurosci (2025). https:\/\/doi.org\/10.1038\/s41593-025-01986-3<\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;<strong><span style=\"color: #ff0000;\">How brain networks connected by labile synapses store new information without catastrophically overwriting previous memories remains poorly understood<\/span><\/strong>. To examine this, we tracked the same population of hippocampal CA1 place cells (PCs) as mice learned a task for 7\u2009days. We found evidence of memory formation as both the number of PCs maintaining a stable place field and the stability of individual PCs progressively increased across the week until most of the representation was composed of long-term stable PCs. <strong><span style=\"color: #ff0000;\">The stable PCs disproportionately represented task-related learned information, were retrieved earlier within a behavioral session and showed a strong correlation with behavioral performance<\/span><\/strong>. Both the initial formation of PCs and their retrieval on subsequent days were accompanied by prominent signs of behavioral timescale synaptic plasticity (BTSP), suggesting that even <strong><span style=\"color: #ff0000;\">stable PCs were re-formed by synaptic plasticity each session<\/span><\/strong>. Further experimental evidence supported by a cascade-type state model indicates that <strong><span style=\"color: #ff0000;\">CA1 PCs increase their stability each day they are active, eventually forming a highly stable population<\/span><\/strong>. The results suggest that <strong><span style=\"color: #ff0000;\">CA1 memory is implemented by an increase in the likelihood of new neuron-specific synaptic plasticity<\/span><\/strong>, as opposed to extensive long-term synaptic weight stabilization.&#8221;<\/p>\n<p style=\"text-align: justify;\">Sachin P. Vaidya, Guanchun Li, Raymond A. Chitwood, Yiding Li &amp; Jeffrey C. Magee. <a href=\"https:\/\/www.nature.com\/articles\/s41593-025-01986-3\"><strong>Formation of an expanding memory representation in the hippocampus<\/strong><\/a>. Nat Neurosci (2025). https:\/\/doi.org\/10.1038\/s41593-025-01986-3<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Sachin P. Vaidya, Guanchun Li, Raymond A. Chitwood, Yiding Li &amp; Jeffrey C. Magee. Formation of an expanding memory representation in the hippocampus. Nat Neurosci (2025). https:\/\/doi.org\/10.1038\/s41593-025-01986-3 Abstract &#8220;How brain networks connected by labile synapses store new information without catastrophically overwriting previous memories remains poorly understood. To examine this, we tracked the same population of [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[346,519],"tags":[833,349,882],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3213"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3213"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3213\/revisions"}],"predecessor-version":[{"id":3214,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3213\/revisions\/3214"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3213"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3213"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3213"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}