{"id":3226,"date":"2025-08-29T13:49:10","date_gmt":"2025-08-29T03:49:10","guid":{"rendered":"https:\/\/braininspirednavigation.com\/?p=3226"},"modified":"2025-08-29T13:49:10","modified_gmt":"2025-08-29T03:49:10","slug":"how-allothetic-and-idiothetic-spatial-cues-control-the-multiplexed-theta-phase-coding-of-place-cells","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=3226","title":{"rendered":"How allothetic and idiothetic spatial cues control the multiplexed theta phase coding of place cells?"},"content":{"rendered":"<p style=\"text-align: justify;\">Sueoka, Y., Jayakumar, R.P., Madhav, M.S. et al. <a href=\"https:\/\/www.nature.com\/articles\/s41593-025-02038-6\"><strong>Allothetic and idiothetic spatial cues control the multiplexed theta phase coding of place cells<\/strong><\/a>. Nat Neurosci (2025). https:\/\/doi.org\/10.1038\/s41593-025-02038-6<\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;<strong><span style=\"color: #ff0000;\">Theta oscillation is considered a temporal scaffold for hippocampal computations that organizes the activity of spatially tuned cells known as place cells<\/span><\/strong>. Late phases of theta support prospective spatial representation via phase \u2018precession\u2019. In contrast, some studies have hypothesized that early phases of theta may subserve both retrospective spatial representation via phase \u2018procession\u2019 and the encoding of new associations. Here, combining virtual reality, electrophysiology and computational modeling, <span style=\"color: #ff0000;\"><strong>we provide experimental evidence for such a functionally multiplexed phase code and describe how distinct spatial inputs control its manifestation<\/strong><\/span>. Specifically, <strong><span style=\"color: #ff0000;\">when rats continuously learned new associations between external landmark (allothetic) cues and self-motion (idiothetic) cues, phase \u2018precession\u2019 remained intact, allowing continuous prediction of future positions<\/span><\/strong>. Conversely, phase \u2018procession\u2019 was diminished, matching the putative role in encoding at the early theta phase. <strong><span style=\"color: #ff0000;\">This multiplexed phase code may serve as a general circuit logic for alternating different computations at a sub-second scale<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Sueoka, Y., Jayakumar, R.P., Madhav, M.S. et al. <a href=\"https:\/\/www.nature.com\/articles\/s41593-025-02038-6\"><strong>Allothetic and idiothetic spatial cues control the multiplexed theta phase coding of place cells<\/strong><\/a>. Nat Neurosci (2025). https:\/\/doi.org\/10.1038\/s41593-025-02038-6<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Sueoka, Y., Jayakumar, R.P., Madhav, M.S. et al. Allothetic and idiothetic spatial cues control the multiplexed theta phase coding of place cells. Nat Neurosci (2025). https:\/\/doi.org\/10.1038\/s41593-025-02038-6 Abstract &#8220;Theta oscillation is considered a temporal scaffold for hippocampal computations that organizes the activity of spatially tuned cells known as place cells. Late phases of theta support prospective [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[346,762],"tags":[1473,1474,104,1475],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3226"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3226"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3226\/revisions"}],"predecessor-version":[{"id":3227,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3226\/revisions\/3227"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3226"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3226"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3226"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}