{"id":3232,"date":"2025-09-05T19:23:01","date_gmt":"2025-09-05T09:23:01","guid":{"rendered":"https:\/\/braininspirednavigation.com\/?p=3232"},"modified":"2025-09-05T19:31:39","modified_gmt":"2025-09-05T09:31:39","slug":"how-cooperative-actions-of-interneuron-families-support-the-hippocampal-spatial-code","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=3232","title":{"rendered":"How cooperative actions of interneuron families support the hippocampal spatial code?"},"content":{"rendered":"<p style=\"text-align: justify;\">Manuel Valero, Pablo Abad-Perez, Andrea Gallardo, Marta Picco, Raquel Garc\u00eda-Hernandez, Jorge Brotons, Anel Mart\u00ednez-F\u00e9lix, Robert Machold, Bernardo Rudy, Gy\u00f6rgy Buzs\u00e1ki. <a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.adv5638\"><strong>Cooperative actions of interneuron families support the hippocampal spatial code<\/strong><\/a>. Science 389,eadv5638(2025). DOI:10.1126\/science.adv5638<\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;<strong><span style=\"color: #ff0000;\">Identifying the computational roles of different neuron families is crucial for understanding neural networks<\/span><\/strong>. Most neural diversity is embodied in various types of \u03b3-aminobutyric acid\u2013mediated (GABAergic) interneurons, grouped into four major families. <strong><span style=\"color: #ff0000;\">We collected datasets of opto-tagged neurons from all four families, along with excitatory neurons, from both the neocortex and hippocampus<\/span><\/strong>. The physiological features of these neurons were used to train a machine learning classifier, which subsequently inferred specific interneuron families in large-scale recordings. This combined approach enabled the reconstruction of synaptic connectivity motifs across interneuron family members. We further showed that these motifs differentially control the place field features of pyramidal neurons. <strong><span style=\"color: #ff0000;\">Our findings attribute a prominent role to interneurons in the formation of a flexible cognitive map<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Manuel Valero et al. ,<a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.adv5638\"><strong>Cooperative actions of interneuron families support the hippocampal spatial code<\/strong><\/a>. Science 389,eadv5638(2025). DOI:10.1126\/science.adv5638<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Manuel Valero, Pablo Abad-Perez, Andrea Gallardo, Marta Picco, Raquel Garc\u00eda-Hernandez, Jorge Brotons, Anel Mart\u00ednez-F\u00e9lix, Robert Machold, Bernardo Rudy, Gy\u00f6rgy Buzs\u00e1ki. Cooperative actions of interneuron families support the hippocampal spatial code. Science 389,eadv5638(2025). DOI:10.1126\/science.adv5638 Abstract &#8220;Identifying the computational roles of different neuron families is crucial for understanding neural networks. Most neural diversity is embodied in various [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[987,96,346],"tags":[1481,1483,1482],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3232"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3232"}],"version-history":[{"count":2,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3232\/revisions"}],"predecessor-version":[{"id":3234,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3232\/revisions\/3234"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3232"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3232"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3232"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}