{"id":3247,"date":"2025-10-26T14:02:37","date_gmt":"2025-10-26T04:02:37","guid":{"rendered":"https:\/\/braininspirednavigation.com\/?p=3247"},"modified":"2025-10-26T14:02:37","modified_gmt":"2025-10-26T04:02:37","slug":"how-environmental-novelty-modulate-rapid-cortical-plasticity-during-navigation","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=3247","title":{"rendered":"How environmental novelty modulate rapid cortical plasticity during navigation?"},"content":{"rendered":"<p style=\"text-align: justify;\">Alexander Attinger, Antonia Drinnenberg, Can Dong, Charu Ramakrishnan, La\u2019Akea Siverts, Tanya L Daigle, Bosiljka Tasic, Hongkui Zeng, Sean Quirin, Karl Deisseroth, Lisa M Giocomo. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2025.10.21.683723v1\"><strong>Environmental Novelty Modulates Rapid Cortical Plasticity During Navigation<\/strong><\/a>.\u00a0<br \/>\nbioRxiv 2025.10.21.683723; doi: https:\/\/doi.org\/10.1101\/2025.10.21.683723<\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;<strong><span style=\"color: #ff0000;\">In novel environments, animals quickly learn to navigate, and position-correlated spatial representations rapidly emerge in both the retrosplenial cortex (RSC) and primary visual cortex (V1)<\/span><\/strong>. However, <strong><span style=\"color: #ff0000;\">the role of plasticity in building these spatial representations, and how experience modulates this process, are not well understood<\/span><\/strong>. Here, we investigated <span style=\"color: #ff0000;\"><strong>the plasticity of spatial representations with real-time, cellular-resolution read and write control of neural activity<\/strong><\/span> using two-photon calcium imaging combined with holographic optogenetic stimulation in mice navigating virtual reality environments. Targeted stimulation of individual layer 2\/3 neurons rapidly biased neural activity towards stimulation-paired locations in novel, but not familiar, environments. In contrast, RSC layer 5 neurons exhibited stimulation-induced plasticity regardless of environmental familiarity. <strong><span style=\"color: #ff0000;\">These findings reveal a layer-specific, experience-dependent modulation of plasticity and offer a framework for how neocortical spatial representations strike a balance between stability of familiar environments with flexibility for continuous updates of relevant context information<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Alexander Attinger, Antonia Drinnenberg, Can Dong, Charu Ramakrishnan, La\u2019Akea Siverts, Tanya L Daigle, Bosiljka Tasic, Hongkui Zeng, Sean Quirin, Karl Deisseroth, Lisa M Giocomo. <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2025.10.21.683723v1\"><strong>Environmental Novelty Modulates Rapid Cortical Plasticity During Navigation<\/strong><\/a>.\u00a0<br \/>\nbioRxiv 2025.10.21.683723; doi: https:\/\/doi.org\/10.1101\/2025.10.21.683723<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Alexander Attinger, Antonia Drinnenberg, Can Dong, Charu Ramakrishnan, La\u2019Akea Siverts, Tanya L Daigle, Bosiljka Tasic, Hongkui Zeng, Sean Quirin, Karl Deisseroth, Lisa M Giocomo. Environmental Novelty Modulates Rapid Cortical Plasticity During Navigation.\u00a0 bioRxiv 2025.10.21.683723; doi: https:\/\/doi.org\/10.1101\/2025.10.21.683723 Abstract &#8220;In novel environments, animals quickly learn to navigate, and position-correlated spatial representations rapidly emerge in both the retrosplenial [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[987,346],"tags":[1192,1489,85,375],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3247"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3247"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3247\/revisions"}],"predecessor-version":[{"id":3248,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3247\/revisions\/3248"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3247"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3247"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3247"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}