{"id":3261,"date":"2026-03-24T15:26:10","date_gmt":"2026-03-24T05:26:10","guid":{"rendered":"https:\/\/braininspirednavigation.com\/?p=3261"},"modified":"2026-03-24T15:26:10","modified_gmt":"2026-03-24T05:26:10","slug":"how-cross-scale-dynamics-are-jointly-organized-in-space-and-time-and-how-this-spatiotemporal-organization-supports-flexible-hierarchical-processing-in-the-brain","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=3261","title":{"rendered":"How cross-scale dynamics are jointly organized in space and time, and how this spatiotemporal organization supports flexible hierarchical processing in the brain?"},"content":{"rendered":"<p style=\"text-align: justify;\">Harris, B., Gong, P. <a href=\"https:\/\/www.nature.com\/articles\/s41467-026-68893-4\"><strong>Nested spatiotemporal theta\u2013gamma waves organize hierarchical processing across the mouse visual cortex<\/strong><\/a>. Nat Commun 17, 2629 (2026). https:\/\/doi.org\/10.1038\/s41467-026-68893-4<\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;<strong><span style=\"color: #ff0000;\">The brain processes visual information across diverse spatial and temporal scales, but the dynamics that bridge these scales remain poorly understood<\/span><\/strong>. Here, we analyze Neuropixels recordings from mouse visual cortex during a visual change-detection task and uncover a nested spatiotemporal structure linking low-frequency \u03b8, high-frequency \u03b3, and neuronal spiking across cortical layers and areas. \u03b8 forms broad traveling waves that flexibly switch direction across a stimulus presentation. Following stimulus onset, top-down \u03b8 propagates from deep to superficial layers and from higher- to lower-order areas, but after stimulus offset, bottom-up \u03b8 travels in the reverse direction. These nonstationary \u03b8 waves predict behavioral responses to changes in stimulus content. In contrast, \u03b3 activity appears as brief, spatially localized packets that sharpen with stimulus onset. Extending conventional cross-frequency coupling analyses, we show that both \u03b3 packets and neuronal spiking are phase-locked to the traveling \u03b8 waves. <strong><span style=\"color: #ff0000;\">This cross-scale coupling exhibits systematic gradients across layers and areas aligned with the visual hierarchy<\/span><\/strong>. Together, <strong><span style=\"color: #ff0000;\">these findings reveal a spatiotemporal \u03b8\u2013\u03b3 neural code that multiplexes bottom-up and top-down information, linking cross-scale dynamics to adaptive hierarchical visual processing<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Harris, B., Gong, P. <a href=\"https:\/\/www.nature.com\/articles\/s41467-026-68893-4\"><strong>Nested spatiotemporal theta\u2013gamma waves organize hierarchical processing across the mouse visual cortex<\/strong><\/a>. Nat Commun 17, 2629 (2026). https:\/\/doi.org\/10.1038\/s41467-026-68893-4<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Harris, B., Gong, P. Nested spatiotemporal theta\u2013gamma waves organize hierarchical processing across the mouse visual cortex. Nat Commun 17, 2629 (2026). https:\/\/doi.org\/10.1038\/s41467-026-68893-4 Abstract &#8220;The brain processes visual information across diverse spatial and temporal scales, but the dynamics that bridge these scales remain poorly understood. Here, we analyze Neuropixels recordings from mouse visual cortex during a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[114,987,96,346],"tags":[1497,1495,1496,652],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3261"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3261"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3261\/revisions"}],"predecessor-version":[{"id":3262,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3261\/revisions\/3262"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3261"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3261"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3261"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}