{"id":3263,"date":"2026-03-27T11:02:27","date_gmt":"2026-03-27T01:02:27","guid":{"rendered":"https:\/\/braininspirednavigation.com\/?p=3263"},"modified":"2026-03-27T11:02:27","modified_gmt":"2026-03-27T01:02:27","slug":"how-topographic-ca1-input-shape-subicular-spatial-coding","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=3263","title":{"rendered":"How topographic CA1 input shape subicular spatial coding?"},"content":{"rendered":"<p style=\"text-align: justify;\">Yanjun Sun, Daniel T. Pederick, Xiangmin Xu, Liqun Luo, Lisa M. Giocomo. <a href=\"https:\/\/www.biorxiv.org\/content\/10.64898\/2026.03.24.714092v1\"><strong>Topographic CA1 input shapes subicular spatial coding<\/strong><\/a>. bioRxiv 2026.03.24.714092; doi: https:\/\/doi.org\/10.64898\/2026.03.24.714092<\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;<strong><span style=\"color: #ff0000;\">Topographic organization characterizes hippocampal circuits, yet its functional significance remains unclear<\/span><\/strong>. By selectively disrupting CA1-to-subiculum topographic projections in latrophilin-2 conditional knockout mice, <strong><span style=\"color: #ff0000;\">we show that precise topography shapes the anatomical distribution of subicular spatial coding while preserving single-cell tuning<\/span><\/strong>. Disrupted topography also selectively impairs boundary vector coding and long-term network stability. Thus, <strong><span style=\"color: #ff0000;\">CA1 inputs provide an indispensable scaffold for organizing subicular spatial maps and dynamics<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Yanjun Sun, Daniel T. Pederick, Xiangmin Xu, Liqun Luo, Lisa M. Giocomo. <a href=\"https:\/\/www.biorxiv.org\/content\/10.64898\/2026.03.24.714092v1\"><strong>Topographic CA1 input shapes subicular spatial coding<\/strong><\/a>. bioRxiv 2026.03.24.714092; doi: https:\/\/doi.org\/10.64898\/2026.03.24.714092<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Yanjun Sun, Daniel T. Pederick, Xiangmin Xu, Liqun Luo, Lisa M. Giocomo. Topographic CA1 input shapes subicular spatial coding. bioRxiv 2026.03.24.714092; doi: https:\/\/doi.org\/10.64898\/2026.03.24.714092 Abstract &#8220;Topographic organization characterizes hippocampal circuits, yet its functional significance remains unclear. By selectively disrupting CA1-to-subiculum topographic projections in latrophilin-2 conditional knockout mice, we show that precise topography shapes the anatomical distribution [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[987,96,419],"tags":[901,1499,1498],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3263"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3263"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3263\/revisions"}],"predecessor-version":[{"id":3264,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3263\/revisions\/3264"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3263"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3263"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3263"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}