{"id":3271,"date":"2026-04-06T09:35:00","date_gmt":"2026-04-05T23:35:00","guid":{"rendered":"https:\/\/braininspirednavigation.com\/?p=3271"},"modified":"2026-04-06T09:35:00","modified_gmt":"2026-04-05T23:35:00","slug":"how-entorhinal-cortex-represent-task-relevant-remote-locations-independently-of-ca1","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=3271","title":{"rendered":"How entorhinal cortex represent task-relevant remote locations independently of CA1?"},"content":{"rendered":"<p style=\"text-align: justify;\">Emily A. Aery Jones, Isabel I. C. Low, Frances S. Cho &amp; Lisa M. Giocomo. <a href=\"https:\/\/www.nature.com\/articles\/s41593-026-02232-0\"><strong>Entorhinal cortex represents task-relevant remote locations independently of CA1<\/strong><\/a>. Nat Neurosci (2026). https:\/\/doi.org\/10.1038\/s41593-026-02232-0<\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;Neurons can collectively represent the current sensory experience during exploration or remote experiences during immobility. Remote representations can reflect learned associations and support learning. <strong><span style=\"color: #ff0000;\">Neurons in medial entorhinal cortex (MEC) represent the animal\u2019s current location during movement, but little is known about MEC representations during immobility<\/span><\/strong>. We recorded hundreds of neurons simultaneously in MEC and CA1 as mice learned to associate pairs of rewarded locations. <strong><span style=\"color: #ff0000;\">During immobility, the MEC neural population frequently represented positions far from the animal\u2019s location (\u2018nonlocal coding\u2019)<\/span><\/strong>. Cells with spatial firing fields at remote locations drove nonlocal coding, even as cells representing the current position remained active. While MEC nonlocal coding has been reported during sharp-wave ripples in CA1, <strong><span style=\"color: #ff0000;\">we observed nonlocal coding more often outside of ripples and saw less CA1\u2013MEC coordination during nonlocal coding<\/span><\/strong>. Further, nonlocal coding preferentially represented remote task-relevant locations at appropriate times. Together, <strong><span style=\"color: #ff0000;\">this work suggests that MEC nonlocal coding could strengthen associations between locations independently from CA1<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Emily A. Aery Jones, Isabel I. C. Low, Frances S. Cho &amp; Lisa M. Giocomo. <a href=\"https:\/\/www.nature.com\/articles\/s41593-026-02232-0\"><strong>Entorhinal cortex represents task-relevant remote locations independently of CA1<\/strong><\/a>. Nat Neurosci (2026). https:\/\/doi.org\/10.1038\/s41593-026-02232-0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Emily A. Aery Jones, Isabel I. C. Low, Frances S. Cho &amp; Lisa M. Giocomo. Entorhinal cortex represents task-relevant remote locations independently of CA1. Nat Neurosci (2026). https:\/\/doi.org\/10.1038\/s41593-026-02232-0 Abstract &#8220;Neurons can collectively represent the current sensory experience during exploration or remote experiences during immobility. Remote representations can reflect learned associations and support learning. Neurons in [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[987,96,346],"tags":[901,829,1502,1501,1500],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3271"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3271"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3271\/revisions"}],"predecessor-version":[{"id":3272,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3271\/revisions\/3272"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3271"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3271"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3271"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}