{"id":3288,"date":"2026-05-21T16:12:12","date_gmt":"2026-05-21T06:12:12","guid":{"rendered":"https:\/\/braininspirednavigation.com\/?p=3288"},"modified":"2026-05-21T16:12:12","modified_gmt":"2026-05-21T06:12:12","slug":"how-hippocampal-neocortical-communication-reconfigure-predetermined-circuit-motifs-to-flexibly-encode-experiences","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=3288","title":{"rendered":"How hippocampal\u2013neocortical communication reconfigure predetermined circuit motifs to flexibly encode experiences?"},"content":{"rendered":"<p style=\"text-align: justify;\">Joaquin Gonzalez, Mih\u00e1ly V\u00f6r\u00f6slakos, Deren Aykan, Nina Soto, Noam Nitzan, Rachel Swanson, Mursel Karadas, Zhe Sage Chen &amp; Gy\u00f6rgy Buzs\u00e1ki. <a href=\"https:\/\/www.nature.com\/articles\/s41586-026-10481-z\"><strong>Subspace communication in the hippocampal\u2013retrosplenial axis<\/strong><\/a>. Nature (2026). https:\/\/doi.org\/10.1038\/s41586-026-10481-z<\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;<strong><span style=\"color: #ff0000;\">The capacity of hippocampal circuits to transform inputs into downstream outputs is fundamental to navigation and memory, yet the circuit-level mechanisms that enable this flexibility in adapting to experience remain unclear<\/span><\/strong>. Here we approach this problem by performing large-scale (up to 1,024 channel) recordings across the hippocampal\u2013retrosplenial cortex (RSC) circuit in behaving mice, enabling simultaneous access to spiking activity in dentate gyrus (DG), CA3, CA2, CA1 and RSC. On the basis of a linear dimensionality-reduction technique known as partial canonical correlation analysis, <strong><span style=\"color: #ff0000;\">we identify low-dimensional communication subspaces1 between two regions while accounting for influences from a third area<\/span><\/strong>. <strong><span style=\"color: #ff0000;\">These subspaces captured distinct input\u2013output transformations in the CA1 region, linking upstream hippocampal activity (DG, CA3 and CA2) to downstream cortical targets (RSC)<\/span><\/strong>. Intrinsic firing properties and anatomical location constrained subspace memberships\u2014members were mapped to deep sublayers of the CA3\u2013CA1\u2013RSC axis during both spatial and non-spatial tasks. <strong><span style=\"color: #ff0000;\">These subspaces could recombine overlapping neuronal pools to support distinct interareal interactions across changing experiences and brain states<\/span><\/strong>. Reactivation patterns of CA1\u2013CA3 subspaces, but not those of CA1\u2013RSC, during post-experience sleep correlated with replay, reflecting a plasticity\u2013stability balance in the input\u2013output transformation along the hippocampal\u2013retrosplenial axis. <strong><span style=\"color: #ff0000;\">Our findings suggest a model in which hippocampal\u2013neocortical communication reconfigures predetermined circuit motifs to flexibly encode experiences<\/span><\/strong>.&#8221;<\/p>\n<p style=\"text-align: justify;\">Joaquin Gonzalez, Mih\u00e1ly V\u00f6r\u00f6slakos, Deren Aykan, Nina Soto, Noam Nitzan, Rachel Swanson, Mursel Karadas, Zhe Sage Chen &amp; Gy\u00f6rgy Buzs\u00e1ki. <a href=\"https:\/\/www.nature.com\/articles\/s41586-026-10481-z\"><strong>Subspace communication in the hippocampal\u2013retrosplenial axis<\/strong><\/a>. Nature (2026). https:\/\/doi.org\/10.1038\/s41586-026-10481-z<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Joaquin Gonzalez, Mih\u00e1ly V\u00f6r\u00f6slakos, Deren Aykan, Nina Soto, Noam Nitzan, Rachel Swanson, Mursel Karadas, Zhe Sage Chen &amp; Gy\u00f6rgy Buzs\u00e1ki. Subspace communication in the hippocampal\u2013retrosplenial axis. Nature (2026). https:\/\/doi.org\/10.1038\/s41586-026-10481-z Abstract &#8220;The capacity of hippocampal circuits to transform inputs into downstream outputs is fundamental to navigation and memory, yet the circuit-level mechanisms that enable this flexibility [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[114,987,96],"tags":[1512,568,875,1511,1510],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3288"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3288"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3288\/revisions"}],"predecessor-version":[{"id":3289,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3288\/revisions\/3289"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3288"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3288"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3288"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}