{"id":3308,"date":"2026-10-24T13:15:41","date_gmt":"2026-10-24T03:15:41","guid":{"rendered":"https:\/\/braininspirednavigation.com\/?p=3308"},"modified":"2026-10-24T13:15:41","modified_gmt":"2026-10-24T03:15:41","slug":"how-hippocampal-brain-machine-interface-based-navigation-reveals-ca1-representations-of-intended-actions","status":"publish","type":"post","link":"https:\/\/braininspirednavigation.com\/?p=3308","title":{"rendered":"How hippocampal brain-machine interface-based navigation reveals CA1 representations of intended actions?"},"content":{"rendered":"<p style=\"text-align: justify;\">Charles Micou, Hinze Ho, Timothy O\u2019Leary, Julija Krupic. <a href=\"https:\/\/www.biorxiv.org\/content\/10.64898\/2026.05.11.724143v1\"><strong>Hippocampal brain-machine interface-based navigation reveals CA1 representations of intended actions<\/strong><\/a>. bioRxiv 2026.05.11.724143; doi: https:\/\/doi.org\/10.64898\/2026.05.11.724143<\/p>\n<p style=\"text-align: justify;\">Abstract<br \/>\n&#8220;<strong><span style=\"color: #ff0000;\">The hippocampus uses external stimuli and self-motion to construct cognitive maps critical for navigation<\/span><\/strong>. However, <strong><span style=\"color: #ff0000;\">these maps can also be activated independently of external inputs and movements, reflecting an internal ability to control the map<\/span><\/strong>. The neural basis of such internal control remains unknown. To address this, <strong><span style=\"color: #ff0000;\">we used a brain-machine interface (BMI) to drive navigation in mice directly from real-time hippocampal activity<\/span><\/strong>. In this condition, CA1 place codes rapidly reconfigured to disregard locomotion-related input. By comparing BMI-controlled navigation, locomotion-controlled navigation, and passive playback of predetermined routes, <strong><span style=\"color: #ff0000;\">we found evidence of CA1 place cell responses that emerge specifically in conditions in which animals can causally influence their travel<\/span><\/strong>. Our findings thus indicate that agency is represented by a distinct place cell code.&#8221;<\/p>\n<p style=\"text-align: justify;\">Charles Micou, Hinze Ho, Timothy O\u2019Leary, Julija Krupic. <a href=\"https:\/\/www.biorxiv.org\/content\/10.64898\/2026.05.11.724143v1\"><strong>Hippocampal brain-machine interface-based navigation reveals CA1 representations of intended actions<\/strong><\/a>. bioRxiv 2026.05.11.724143; doi: https:\/\/doi.org\/10.64898\/2026.05.11.724143<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Charles Micou, Hinze Ho, Timothy O\u2019Leary, Julija Krupic. Hippocampal brain-machine interface-based navigation reveals CA1 representations of intended actions. bioRxiv 2026.05.11.724143; doi: https:\/\/doi.org\/10.64898\/2026.05.11.724143 Abstract &#8220;The hippocampus uses external stimuli and self-motion to construct cognitive maps critical for navigation. However, these maps can also be activated independently of external inputs and movements, reflecting an internal ability to [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[96,346],"tags":[1525,1524,1526,85],"_links":{"self":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3308"}],"collection":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3308"}],"version-history":[{"count":1,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3308\/revisions"}],"predecessor-version":[{"id":3309,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=\/wp\/v2\/posts\/3308\/revisions\/3309"}],"wp:attachment":[{"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3308"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3308"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/braininspirednavigation.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3308"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}