Category: Neural Basis of Navigation

What’s human neural dynamics of real-world and imagined navigation?

Martin Seeber, Matthias Stangl, Mauricio Vallejo Martelo, Uros Topalovic, Sonja Hiller, Casey H. Halpern, Jean-Philippe Langevin, Vikram R. Rao, Itzhak Fried, Dawn Eliashiv & Nanthia Suthana. Human neural dynamics of real-world and imagined navigation. Nat Hum Behav (2025). https://doi.org/10.1038/s41562-025-02119-3…

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How to construct future behavior in the hippocampal formation through composition and replay?

Jacob J. W. Bakermans, Joseph Warren, James C. R. Whittington & Timothy E. J. Behrens. Constructing future behavior in the hippocampal formation through composition and replay. Nat Neurosci (2025). https://doi.org/10.1038/s41593-025-01908-3

Abstract
The hippocampus is critical for memory, imagination

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How grid cell modules could emerge from local interaction?

Khona, M., Chandra, S. & Fiete, I. Global modules robustly emerge from local interactions and smooth gradientsNature (2025). https://doi.org/10.1038/s41586-024-08541-3

Abstract
“Modular structure and function are ubiquitous in biology, from the organization of animal brains and bodies to the …

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How memory mechanisms shape navigational strategies in Drosophila?

Andrew F. Siliciano, Sun Minni, Chad Morton, Charles K. Dowell, Noelle B. Eghbali, Juliana Y. Rhee, L. F. Abbott, Vanessa Ruta. A vector-based strategy for olfactory navigation in Drosophila. bioRxiv 2025.02.15.638426; doi: https://doi.org/10.1101/2025.02.15.638426

Abstract
“Odors serve as essential cues …

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How learning produces an orthogonalized state machine in the hippocampus?

Sun, W., Winnubst, J., Natrajan, M. et al. Learning produces an orthogonalized state machine in the hippocampus. Nature (2025). https://doi.org/10.1038/s41586-024-08548-w

Abstract
Cognitive maps confer animals with flexible intelligence by representing spatial, temporal and abstract relationships that can be

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How left–right-alternating theta sweeps in the entorhinal–hippocampal positioning system provides an efficient ‘look around’ mechanism for sampling locations beyond the travelled path?

Abraham Z. Vollan, Richard J. Gardner, May-Britt Moser & Edvard I. Moser. Left–right-alternating theta sweeps in entorhinal–hippocampal maps of space. Nature (2025). https://doi.org/10.1038/s41586-024-08527-1

Abstract
Place cells in the hippocampus and grid cells in the entorhinal cortex are elements

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How does the brain actually represent the real world with its complex, multianimal settings?

Saikat Ray, Itay Yona, Nadav Elami, Shaked Palgi, Kenneth W. Latimer, Bente Jacobsen, Menno P. Witter, Liora Las, and Nachum Ulanovsky. Hippocampal coding of identity, sex, hierarchy, and affiliation in a social group of wild fruit bats. Science 387,eadk9385(2025). …

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How behavior incorporated into visual compass like route learning and recapitulation strategies might enable convergence to a learned route and its destination?

Amany Azevedo Amin, Andrew Philippides, Paul Graham. Ant visual route navigation: How the fine details of behaviour promote successful route performance and convergence. bioRxiv 2025.01.16.633342; doi: https://doi.org/10.1101/2025.01.16.633342

Abstract
“Individually foraging ants use egocentric views as a dominant navigation strategy …

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How does one brain circuit encode memories of both places and events?

Sarthak Chandra, Sugandha Sharma, Rishidev Chaudhuri & Ila Fiete. Episodic and associative memory from spatial scaffolds in the hippocampus. Nature (2025). https://doi.org/10.1038/s41586-024-08392-y

Abstract
“Hippocampal circuits in the brain enable two distinct cognitive functions: the construction of spatial maps for

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How grid cell firing patterns rapidly adapt to novel or changing environmental features on a timescale relevant to behaviour?

Wen, J.H., Sorscher, B., Aery Jones, E.A. et al. One-shot entorhinal maps enable flexible navigation in novel environments. Nature (2024). https://doi.org/10.1038/s41586-024-08034-3

Abstract
Animals must navigate changing environments to find food, shelter or mates. In mammals, grid cells in …

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How the representations of space and time interact in the hippocampal memory system?

Chen, Shijie, Ning Cheng, Xiaojing Chen, and Cheng Wang. “Integration and competition between space and time in the hippocampus.” Neuron (2024).

Summary
“Episodic memory is organized in both spatial and temporal contexts. The hippocampus is crucial for episodic

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How learning-associated astrocyte ensembles regulate memory recall?

Williamson, M.R., Kwon, W., Woo, J. et al. Learning-associated astrocyte ensembles regulate memory recall. Nature (2024). https://doi.org/10.1038/s41586-024-08170-w

Abstract
The physical manifestations of memory formation and recall are fundamental questions that remain unresolved1. At the cellular level, ensembles …

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How bats use environmental acoustic information to perform acoustic cognitive map–based navigation?

Aya Goldshtein, Xing Chen, Eran Amichai, Arjan Boonman, Lee Harten, Omer Yinon,Yotam Orchan, Ran Nathan, Sivan Toledo, Iain D. Couzin, Yossi Yovel. Acoustic cognitive map–based navigation in echolocating bats.Science 386,561-567(2024).DOI:10.1126/science.adn6269

Editor’s summary
“Insectivorous bats are well known to use …

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Where visual objects are encoded in the mouse brain or how visual objects impact processing within the spatial navigation system?

Dominique Siegenthaler, Henry Denny, Sofía Skromne Carrasco, Johanna Luise Mayer, Adrien Peyrache, Stuart Trenholm, Émilie Macé. Visual objects refine head direction coding. bioRxiv 2024.10.21.619417; doi: https://doi.org/10.1101/2024.10.21.619417

Abstract
Animals use visual objects to guide navigation-related behaviors, from hunting prey,

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What are the mechanisms of memory-supporting neuronal dynamics in hippocampal area CA3?

Li, Yiding, John J. Briguglio, Sandro Romani, Jeffrey C. Magee, Eddy Kinganda-Lusamaki, Adrienne Amuri-Aziza, Nicolas Fernandez-Nuñez et al. “Mechanisms of memory-supporting neuronal dynamics in hippocampal area CA3.” Cell 187 (2024): 2030-2051.

 

Summary
Hippocampal CA3 is central to

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