Tag: CA1

How synaptic plasticity underlies place-field formation and memory encoding during navigation?

Gonzalez, K.C., Negrean, A., Liao, Z. et al. Synaptic basis of feature selectivity in hippocampal neurons. Nature (2024). https://doi.org/10.1038/s41586-024-08325-9

Abstract
“A central question in neuroscience is how synaptic plasticity shapes the feature selectivity of neurons in behaving animals1. …

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How are objects and landmarks encoded by the hippocampal neural population for navigation?

Anne Nagelhus, Sebastian O. Andersson, Soledad Gonzalo Cogno, Edvard I. Moser, May-Britt Moser. Object-centered population coding in CA1 of the hippocampus. Neuron 111, 1–14, 2023.

Summary
Objects and landmarks are crucial for guiding navigation and must be integrated

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Which neural circuits utilize relevant cues to initiate integration?

Raphael Heldman, Dongyan Pang, Xiaoliang Zhao, Yingxue Wang. A CA1 circuit motif that signals the start of information integration. bioRxiv 2023.03.12.532295; doi: https://doi.org/10.1101/2023.03.12.532295

Abstract
Integrating information from the recent past is critical for guiding predictions and shaping behavior

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How collective hippocampal coding properties facilitate the stability or precision of the neural code?

Sheintuch, Liron, Nitzan Geva, Daniel Deitch, Alon Rubin, and Yaniv Ziv. “Organization of hippocampal CA3 into correlated cell assemblies supports a stable spatial code.” Cell Reports 42, no. 2 (2023).

Summary
Hippocampal subfield CA3 is thought to

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How brain encode object-location memories?

Yusuke Teratani-Ota, Brian J. Wiltgen. Encoding object-location memories along the proximodistal axis of CA1. bioRxiv 2022.10.17.512601; doi: https://doi.org/10.1101/2022.10.17.512601

Abstract
The hippocampus is thought to combine “what” and “where” information from the cortex so that objects and events can

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How hippocampal neural circuits achieve efficient spatial representations using dynamic hyperbolic geometry?

Huanqiu Zhang, P. Dylan Rich, Albert K. Lee & Tatyana O. Sharpee. Hippocampal spatial representations exhibit a hyperbolic geometry that expands with experience. Nat Neurosci (2022). https://doi.org/10.1038/s41593-022-01212-4

Abstract
Daily experience suggests that we perceive distances near us linearly.

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How direct cortical inputs to hippocampal area CA1 transmit complementary signals for goal-directed navigation?

John C Bowler, Attila Losonczy. Direct Cortical Inputs to Hippocampal Area CA1 Transmit Complementary Signals for Goal-directed Navigation. bioRxiv 2022.11.10.516009; doi: https://doi.org/10.1101/2022.11.10.516009

Summary
“The entorhinal cortex (EC) is central to the brain’s navigation system. Its subregions are conventionally thought …

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How entorhinal cortex directs learning-related changes in CA1 representations?

Christine Grienberger, Jeffrey C. Magee. Entorhinal cortex directs learning-related changes in CA1 representations. Nature (2022). https://doi.org/10.1038/s41586-022-05378-6

Abstract
Learning-related changes in brain activity are thought to underlie adaptive behaviours1,2. For instance, the learning of a reward site by …

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How hippocampal CA2 processes spatial novelty?

Bhasin, Guncha, and Indrajith R. Nair. “Dynamic hippocampal CA2 responses to contextual spatial novelty.” Frontiers in Systems Neuroscience: 79, 2022

Abstract

“Hippocampal place cells are functional units of spatial navigation and are present in all subregions: CA1, CA2, …

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How conjunctive and complementary CA1 hippocampal cell populations relate sensory events to immobility and locomotion?

Samsoon Inayat, Brendan B McAllister, Bruce L McNaughton, Ian Q Whishaw, Majid H Mohajerani. Conjunctive and complementary CA1 hippocampal cell populations relate sensory events to immobility and locomotion. bioRxiv 2022.07.06.498996; doi: https://doi.org/10.1101/2022.07.06.498996

Abstract
The way in which the

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How information about objects is represented in collective dynamics of the hippocampal population?

Anne Nagelhus, Sebastian Andersson, Soledad Gonzalo Cogno, Edvard I. Moser, May-Britt Moser. Object-centered population coding in CA1 of the hippocampus. bioRxiv 2022.07.07.499197; doi: https://doi.org/10.1101/2022.07.07.499197

Abstract
Objects and landmarks are crucial for guiding navigation and must be integrated into

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How do hippocampal individual neurons combine multiple features of the navigation experience, encoding a mixed representation of position, head direction, and speed?

Ledergerber, Debora, Claudia Battistin, Jan Sigurd Blackstad, Richard J. Gardner, Menno P. Witter, May-Britt Moser, Yasser Roudi, and Edvard I. Moser. “Task-dependent mixed selectivity in the subiculum.” Cell Report, Volume 35, Issue 8, 25 May 2021, 109175. 

Highlights…

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