Category: Spatial Memory

How does one brain circuit encode memories of both places and events?

Sarthak Chandra, Sugandha Sharma, Rishidev Chaudhuri & Ila Fiete. Episodic and associative memory from spatial scaffolds in the hippocampus. Nature (2025). https://doi.org/10.1038/s41586-024-08392-y

Abstract
“Hippocampal circuits in the brain enable two distinct cognitive functions: the construction of spatial maps for

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How sleep microstructure organizes memory replay?

Hongyu Chang, Wenbo Tang, Annabella M. Wulf, Thokozile Nyasulu, Madison E. Wolf, Antonio Fernandez-Ruiz & Azahara Oliva. Sleep microstructure organizes memory replay. Nature (2025). https://doi.org/10.1038/s41586-024-08340-w

Abstract
“Recently acquired memories are reactivated in the hippocampus during sleep, an initial step …

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How to understand the neural basis of natural intelligence?

Angelo Forli, Michael M. Yartsev. Understanding the neural basis of natural intelligence. Cell, 2024, Volume 187, Issue 21, 5833 – 5837

Abstract
Understanding the neural basis of natural intelligence necessitates a paradigm shift: from strict reductionism toward …

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How human hippocampal CA3 uses specific functional connectivity rules for efficient associative memory?

Jake F. Watson, Victor Vargas-Barroso, Rebecca J. Morse-Mora, Andrea Navas-Olive, Mojtaba R. Tavakoli, Johann G. Danzl, Matthias Tomschik, Karl Rössler, Peter Jonas. Human hippocampal CA3 uses specific functional connectivity rules for efficient associative memory. Cell, 2024. DOI: 10.1016/j.cell.2024.11.022

Summary…

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How are associative memories formed? Which cells represent a memory, and when are they engaged?

Clément Pouget, Flora Morier, Nadja Treiber, Pablo Fernández García, Nina Mazza, Run Zhang, Isaiah Reeves, Stephen Winston, Mark A. Brimble, Christina K. Kim, Gisella Vetere. Deconstruction of a memory engram reveals distinct ensembles recruited at learning. bioRxiv 2024.12.11.627894; doi: …

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How the brain integrate recent experiences into existing memories ensures that memories contain the most recently available information?

Zaki, Y., Pennington, Z.T., Morales-Rodriguez, D. et al. Offline ensemble co-reactivation links memories across days. Nature (2024). https://doi.org/10.1038/s41586-024-08168-4

Abstract
“Memories are encoded in neural ensembles during learning1,2,3,4,5,6 and are stabilized by post-learning reactivation7,8,9,10,11,12,13,14,15,16,17. Integrating recent experiences into existing memories

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How learning-associated astrocyte ensembles regulate memory recall?

Williamson, M.R., Kwon, W., Woo, J. et al. Learning-associated astrocyte ensembles regulate memory recall. Nature (2024). https://doi.org/10.1038/s41586-024-08170-w

Abstract
The physical manifestations of memory formation and recall are fundamental questions that remain unresolved1. At the cellular level, ensembles …

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What are the mechanisms of memory-supporting neuronal dynamics in hippocampal area CA3?

Li, Yiding, John J. Briguglio, Sandro Romani, Jeffrey C. Magee, Eddy Kinganda-Lusamaki, Adrienne Amuri-Aziza, Nicolas Fernandez-Nuñez et al. “Mechanisms of memory-supporting neuronal dynamics in hippocampal area CA3.” Cell 187 (2024): 2030-2051.

 

Summary
Hippocampal CA3 is central to

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How memory and language are linked at the single-cell level?

D. E. Dijksterhuis et al. ,Pronouns reactivate conceptual representations in human hippocampal neurons.Science 385,1478-1484(2024).DOI:10.1126/science.adr2813

Abstract
“During discourse comprehension, every new word adds to an evolving representation of meaning that accumulates over consecutive sentences and constrains the next words

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How ants use latent learning without map-like representation of space to navigate?

Leo Clement, Sebastian Schwarz, Antoine Wystrach. Latent learning without map-like representation of space in navigating ants. bioRxiv 2024.08.29.610243; doi: https://doi.org/10.1101/2024.08.29.610243

Abstract
“Desert ants are excellent navigators. Each individual learns long foraging routes meandering between the trees and bushes in …

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How shifts in the composition of memory-encoding neuronal ensembles influence the evolution of a memory over time?

Vilde A. Kveim et al. ,Divergent recruitment of developmentally defined neuronal ensembles supports memory dynamics.Science 385,eadk0997(2024).DOI:10.1126/science.adk0997

Editor’s summary
Memories are not fixed; they evolve after encoding and their content can be updated upon changes in external or

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How the hippocampus supports episodic and spatial memory at the same time?

Alexander Nitsch, Naomi de Haas, Mona M. Garvert, Christian F. Doeller. Integrating episodic and spatial context signals in the hippocampus. bioRxiv 2024.06.24.600445; doi: https://doi.org/10.1101/2024.06.24.600445

Abstract
Episodic and spatial memory are the two key components of the mnemonic system

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How bees achieve vertebrate-like, high-level navigation behaviors with far fewer neurons in their brains?

Patel RN, Roberts NS, Kempenaers J, Zadel A, Heinze S. Parallel vector memories in the brain of a bee as foundation for flexible navigation. Proceedings of the National Academy of Sciences. 2024 Jul 23;121(30):e2402509121.

Significance
Insects navigate by

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How to build a bio-inspired hardware implementation of an analog spike-based hippocampus memory model?

Daniel Casanueva-Morato, Alvaro Ayuso-Martinez, Giacomo Indiveri, J P Dominguez-Morales,Gabriel Jimenez-Moreno. A bio-inspired hardware implementation of an analog spike-based hippocampus memory model. TechRxiv. April 03, 2024. DOI: 10.36227/techrxiv.171216721.14143739/v1

Abstract
“The need for processing at the edge the increasing amount of …

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How the medial entorhinal cortex develops during learning and influences memory?

Malone, T.J., Tien, NW., Ma, Y. et al. A consistent map in the medial entorhinal cortex supports spatial memoryNat Commun 15, 1457 (2024). https://doi.org/10.1038/s41467-024-45853-4

Abstract
The medial entorhinal cortex (MEC) is hypothesized to function as a

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Whether associative memory involves temporally correlated spiking of medial temporal lobe (MTL) neurons that exhibit stimulus-specific tuning?

Kunz, L., Staresina, B.P., Reinacher, P.C. et al. Ripple-locked coactivity of stimulus-specific neurons and human associative memory. Nat Neurosci (2024). https://doi.org/10.1038/s41593-023-01550-x

Abstract
“Associative memory enables the encoding and retrieval of relations between different stimuli. To better understand its neural …

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How the activity of entorhinal cells is tied together over time at behaviourally relevant time scales, in the second-to-minute regime?

Soledad Gonzalo Cogno, Horst A. Obenhaus, Ane Lautrup, R. Irene Jacobsen, Claudia Clopath, Sebastian O. Andersson, Flavio Donato, May-Britt Moser & Edvard I. Moser. Minute-scale oscillatory sequences in medial entorhinal cortex. Nature (2023). https://doi.org/10.1038/s41586-023-06864-1

Abstract
The medial entorhinal

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How to build a dynamic attractor network model of memory formation, reinforcement and forgetting?

Marta Boscaglia, Chiara Gastaldi, Wulfram Gerstner, Rodrigo Quian Quiroga. A dynamic attractor network model of memory formation, reinforcement and forgetting. bioRxiv 2023.12.01.569560; doi: https://doi.org/10.1101/2023.12.01.569560

Abstract
“Empirical evidence shows that memories that are frequently revisited are easy to recall, …

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How hippocampal assembly co-activity and temporally-compressed sequences are complementary codes that support associative and predictive aspects of memory?

Can Liu, Ralitsa Todorova, Wenbo Tang, Azahara Oliva, Antonio Fernandez-Ruiz. Associative and predictive hippocampal codes support memory-guided behaviors.Science 382,eadi8237(2023).DOI:10.1126/science.adi8237

Abstract
“Episodic memory involves learning and recalling associations between items and their spatiotemporal context. Those memories can be further used …

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How navigational systems in the human brain dynamically code for past, present, and future trajectories?

You Cheng, Sam Ling, Chantal E. Stern, Elizabeth R. Chrastil. Navigational systems in the human brain dynamically code for past, present, and future trajectories. bioRxiv 2023.08.22.554387; doi: https://doi.org/10.1101/2023.08.22.554387

Abstract
Navigational trajectory planning requires the interaction of systems that

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What are the mechanisms of memory storage and retrieval in hippocampal area CA3?

Yiding Li, John J. Briguglio, Sandro Romani, Jeffrey C. Magee. Mechanisms of memory storage and retrieval in hippocampal area CA3. bioRxiv 2023.05.30.542781; doi: https://doi.org/10.1101/2023.05.30.542781

Abstract
“Hippocampal area CA3 is thought to play a central role in memory formation and …

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How hippocampal system neurons encode views for memory and navigation in different species?

Hippocampus Special Issue:Hippocampal System Neurons Encoding Views in Different Species
Issue Edited by: Edmund Rolls, Sylvia Wirth , May 2023

“The aim of this Special Issue of Hippocampus (2023) is to bring together papers that address view representations in the

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How the hippocampus encodes, stores and updates learned associations?

Jeremy S. Biane, Max A. Ladow, Fabio Stefanini, Sayi P. Boddu, Austin Fan, Shazreh Hassan, Naz Dundar, Daniel L. Apodaca-Montano, Lexi Zichen Zhou, Varya Fayner, Nicholas I. Woods & Mazen A. Kheirbek. Neural dynamics underlying associative learning in the dorsal

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How distinct hippocampal-prefrontal neural assemblies coordinate memory encoding, maintenance, and recall?

Aleksander P.F. Domanski, Michal T. Kucewicz, Eleonora Russo, Mark D. Tricklebank, Emma S.J. Robinson, Daniel Durstewitz, Matt W. Jones. Distinct hippocampal-prefrontal neural assemblies coordinate memory encoding, maintenance, and recall. Current Biology, 2023.

Summary
Short-term memory enables incorporation of

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Whether or how the brain flexibly represents information about different event components at encoding and during remembering?

Reagh, Z.M., Ranganath, C. Flexible reuse of cortico-hippocampal representations during encoding and recall of naturalistic events. Nat Commun 14, 1279 (2023). https://doi.org/10.1038/s41467-023-36805-5

Abstract
“Although every life event is unique, there are considerable commonalities across events. However, little is known

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What’s the local circuit-basis for spatial navigation and memory processes in hippocampal area CA1?

Tristan Geiller, James B. Priestley, Attila Losonczy. A local circuit-basis for spatial navigation and memory processes in hippocampal area CA1. Current Opinion in Neurobiology. Volume 79, 2023,102701.

Abstract
“The hippocampus is a multi-stage neural circuit that is critical for …

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How the cognitive map is recalled and how the manipulation of distances and directions occurs within the cognitive map?

Teixeira De Almeida, M., Faulmann, I., Seeber, M., Gschwend, K., Maurer, R., & Burra, N. 2023. Electrophysiological correlates of distance and direction processing during cognitive map retrieval: A source analysis. Frontiers in Human Neuroscience, 17, 42.

The aim

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How new learning affects a previously acquired spatial memory representation?

Samuel J Levy, Michael E Hasselmo. Hippocampal remapping induced by new behavior is mediated by spatial context. bioRxiv 2023.02.20.529330; doi: https://doi.org/10.1101/2023.02.20.529330

Abstract
“The hippocampus plays a central role in episodic memory and spatial navigation. Hippocampal neurons form unique representational

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How collective hippocampal coding properties facilitate the stability or precision of the neural code?

Sheintuch, Liron, Nitzan Geva, Daniel Deitch, Alon Rubin, and Yaniv Ziv. “Organization of hippocampal CA3 into correlated cell assemblies supports a stable spatial code.” Cell Reports 42, no. 2 (2023).

Summary
Hippocampal subfield CA3 is thought to

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How the brain avoid systematic erasing of previously encoded memories?

Irene Navarro-Lobato, Adrian Aleman-Zapata, Anumita Samanta, Milan Bogers, Shekhar Narayanan, Abdelrahman Rayan, Alejandra Alonso, Jacqueline van der Meij, Mehdi Khamassi, Zafar Khan, Lisa Genzel. Learning Fast and Slow: Increased cortical plasticity leads to memory interference and enhanced hippocampal-cortical interactions. …

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How unique and predictable elements of memories are stored and reconstructed by efficiently combining both hippocampal and neocortical systems?

Eleanor Spens, Neil Burgess. A Generative Model of Memory Construction and Consolidation. bioRxiv 2023.01.19.524711; doi: https://doi.org/10.1101/2023.01.19.524711

Abstract
“Human episodic memories are (re)constructed, combining unique features with schema-based predictions, and share neural substrates with imagination. They also show systematic schema-based …

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Whether, and how, replay supports both future planning and preserving memories of the past?

G. Elliott Wimmer, Yunzhe Liu, Daniel C. McNamee, and Raymond J. Dolan. Distinct replay signatures for prospective decision-making and memory preservation. PNAS, 120 (6) e2205211120, 2023. 

Significance
The sequential neural reactivation of prior experience, known as replay, is

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How episodic memories are stored within brains?

Sachin P Vaidya, Raymond A Chitwood, Jeffrey C Magee. The formation of an expanding memory representation in the hippocampus. bioRxiv 2023.02.01.526663; doi: https://doi.org/10.1101/2023.02.01.526663

Abstract
How episodic memories are stored within brains is poorly understood. While certain memory-retaining

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Do artificial intelligence (AI) agents learn to build internal spatial representations (or ‘mental’ maps) of their environment as a natural consequence of learning to navigate?

Erik Wijmans, Manolis Savva, Irfan Essa, Stefan Lee, Ari S. Morcos, Dhruv Batra. Emergence of Maps in the Memories of Blind Navigation Agents. arXiv:2301.13261 [cs.AI], 2023. 

Abstact
“Animal navigation research posits that organisms build and maintain internal spatial representations, …

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How navigation and memory processes interact in humans?

Thomas Schreiner, Benjamin J. Griffiths, Merve Kutlu, Christian Vollmar, Elisabeth Kaufmann, Stefanie Quach, Jan Remi, Soheyl Noachtar, Tobias Staudigl. Memory reactivation of real-world spatial orientation revealed by human electrophysiology. bioRxiv 2023.01.27.525854; doi: https://doi.org/10.1101/2023.01.27.525854

Abstract
Spatial navigation and memory

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How the hippocampus incorporates new contextual information into a previously formed and stabilized spatial representation?

Jake Ormond, Simon A. Serka, Joshua P. Johansen. Enhanced reactivation of remapping place cells during aversive learning. Journal of Neuroscience 3 January 2023, JN-RM-1450-22; DOI: 10.1523/JNEUROSCI.1450-22.2022

Abstract
Study of the hippocampal place cell system has greatly enhanced our

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How does the cortex retrieve episodic memories from the hippocampus during memory consolidation?

HaoRan Chang, Ingrid M. Esteves, Adam R. Neumann, Majid H. Mohajerani, Bruce L. McNaughton. Cortical Reactivation of Non-Spatial and Spatial Memory Representations Coordinate with Hippocampus to Form a Memory Dialogue. bioRxiv 2022.12.16.520658; doi: https://doi.org/10.1101/2022.12.16.520658

Abstract
“Episodic memory depends on …

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How dopamine promotes head direction plasticity during orienting movements?

Yvette E. Fisher, Michael Marquis, Isabel D’Alessandro& Rachel I. Wilson. Dopamine promotes head direction plasticity during orienting movements. Nature (2022). https://doi.org/10.1038/s41586-022-05485-4

Abstract
In neural networks that store information in their connection weights, there is a tradeoff between sensitivity

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Whether associative memory involves precisely timed spiking of neurons in the medial temporal lobes that exhibit stimulus-specific tuning?

Lukas Kunz, Bernhard P Staresina, Peter C Reinacher, Armin Brandt, Tim A Guth, Andreas Schulze-Bonhage, Joshua Jacobs. Ripple-locked coactivity of stimulus-specific neurons supports human associative memory. bioRxiv 2022.10.17.512635; doi: https://doi.org/10.1101/2022.10.17.512635

Abstract
Associative memory is the ability to encode

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How to integrate new memories into the hippocampal network activity space?

Gava, G.P., McHugh, S.B., Lefèvre, L. et al. Integrating new memories into the hippocampal network activity space. Nat Neurosci 24, 326–330 (2021). https://doi.org/10.1038/s41593-021-00804-w

Abstract
“By investigating the topology of neuronal co-activity, we found that mnemonic information spans multiple operational …

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How the cross-modal identity of multiple conspecifics are represented in the marmoset hippocampus?

Timothy J Tyree, Michael Metke, Cory T Miller. Cross-Modal Representation of Identity in Primate Hippocampus. bioRxiv 2022.09.12.507611; doi: https://doi.org/10.1101/2022.09.12.507611

Abstract
“Faces and voices are the dominant social signals used to recognize individuals amongst human and nonhuman primates 1–5. Yet, …

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What is known about the role of the hippocampus in processing auditory information, and how the hippocampus itself is shaped by sound?

Alexander J. Billig, Meher Lad, William Sedley, Timothy D. Griffiths. The hearing hippocampus. Progress in Neurobiology, Volume 218, 2022, 102326.

Abstract
The hippocampus has a well-established role in spatial and episodic memory but a broader function has been

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How hippocampal activity supports building predictive models by organizing newly learned information according to its congruence with existing memories?

Adam M. P. Miller, Alex D. Jacob, Adam I. Ramsaran, Mitchell L. De Snoo, Sheena A. Josselyn, Paul W. Frankland. Evolution of predictive memory in the hippocampus. bioRxiv 2022.09.08.507204; doi: https://doi.org/10.1101/2022.09.08.507204

Summary
“The brain organizes experiences into memories that …

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How hippocampal astrocytes encode reward location?

Adi Doron, Alon Rubin, Aviya Benmelech-Chovav, Netai Benaim, Tom Carmi, Ron Refaeli, Nechama Novick, Tirzah Kreisel, Yaniv Ziv & Inbal Goshen. Hippocampal astrocytes encode reward location. Nature (2022). https://doi.org/10.1038/s41586-022-05146-6

Abstract
“Astrocytic calcium dynamics has been implicated in the encoding …

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Whether rats can learn spaces just by observation?

Doublet T, Nosrati M and Kentros CG (2022) Social Learning of a Spatial Task by Observation Alone. Front. Behav. Neurosci. 16:902675. doi: 10.3389/fnbeh.2022.902675

Abstact

“Interactions between conspecifics are central to the acquisition of useful memories in the real world. …

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How conjunctive and complementary CA1 hippocampal cell populations relate sensory events to immobility and locomotion?

Samsoon Inayat, Brendan B McAllister, Bruce L McNaughton, Ian Q Whishaw, Majid H Mohajerani. Conjunctive and complementary CA1 hippocampal cell populations relate sensory events to immobility and locomotion. bioRxiv 2022.07.06.498996; doi: https://doi.org/10.1101/2022.07.06.498996

Abstract
The way in which the

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How the brain associate multiple sensory cues with objects and experience?

Scott Waddell, Zeynep Okray, Pedro F Jacob, Ciara Stern, Kieran Desmond, Nils Otto, Paola Vargas-Gutierrez. Multisensory learning binds modality-specific neurons into a cross-modal memory engram. bioRxiv 2022.07.08.499174; doi: https://doi.org/10.1101/2022.07.08.499174

Abstract
Associating multiple sensory cues with objects and experience

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Whether network oscillation occurs in MEC at behavioural time scales in the second-to-minute regime such as spatial navigation and episodic memory?

Soledad Gonzalo Cogno, Horst A. Obenhaus, Ragnhild Irene Jacobsen, Flavio Donato, May-Britt Moser, Edvard I. Moser. Minute-scale oscillatory sequences in medial entorhinal cortex. bioRxiv 2022.05.02.490273; doi: https://doi.org/10.1101/2022.05.02.490273

Abstract
The medial entorhinal cortex (MEC) hosts many of the brain’s

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How does the brain translate experiences into structured knowledge that allows us to navigate to achieve goals?

Corey Fernandez, Jiefeng Jiang, Shao-Fang Wang, Hannah Choi, Anthony D Wagner. Representational integration and differentiation in the human hippocampus following goal-directed navigation. bioRxiv 2022.04.12.488078; doi: https://doi.org/10.1101/2022.04.12.488078

Abstract
“As we learn, dynamic memory processes build structured knowledge across our experiences. …

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How does the hippocampus rapidly consolidates novel information for spatial navigation?

Brad E. Pfeiffer. Spatial learning drives rapid goal representation in hippocampal ripples without place field accumulation or goal-oriented theta sequences. Journal of Neuroscience 8 April 2022, JN-RM-2479-21; DOI: 10.1523/JNEUROSCI.2479-21.2022

Abstract
The hippocampus is critical for rapid acquisition of

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