Category: Episodic Memory

How does one brain circuit encode memories of both places and events?

Sarthak Chandra, Sugandha Sharma, Rishidev Chaudhuri & Ila Fiete. Episodic and associative memory from spatial scaffolds in the hippocampus. Nature (2025). https://doi.org/10.1038/s41586-024-08392-y

Abstract
“Hippocampal circuits in the brain enable two distinct cognitive functions: the construction of spatial maps for

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How sleep microstructure organizes memory replay?

Hongyu Chang, Wenbo Tang, Annabella M. Wulf, Thokozile Nyasulu, Madison E. Wolf, Antonio Fernandez-Ruiz & Azahara Oliva. Sleep microstructure organizes memory replay. Nature (2025). https://doi.org/10.1038/s41586-024-08340-w

Abstract
“Recently acquired memories are reactivated in the hippocampus during sleep, an initial step …

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How synaptic plasticity underlies place-field formation and memory encoding during navigation?

Gonzalez, K.C., Negrean, A., Liao, Z. et al. Synaptic basis of feature selectivity in hippocampal neurons. Nature (2024). https://doi.org/10.1038/s41586-024-08325-9

Abstract
“A central question in neuroscience is how synaptic plasticity shapes the feature selectivity of neurons in behaving animals1. …

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How human hippocampal CA3 uses specific functional connectivity rules for efficient associative memory?

Jake F. Watson, Victor Vargas-Barroso, Rebecca J. Morse-Mora, Andrea Navas-Olive, Mojtaba R. Tavakoli, Johann G. Danzl, Matthias Tomschik, Karl Rössler, Peter Jonas. Human hippocampal CA3 uses specific functional connectivity rules for efficient associative memory. Cell, 2024. DOI: 10.1016/j.cell.2024.11.022

Summary…

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How are associative memories formed? Which cells represent a memory, and when are they engaged?

Clément Pouget, Flora Morier, Nadja Treiber, Pablo Fernández García, Nina Mazza, Run Zhang, Isaiah Reeves, Stephen Winston, Mark A. Brimble, Christina K. Kim, Gisella Vetere. Deconstruction of a memory engram reveals distinct ensembles recruited at learning. bioRxiv 2024.12.11.627894; doi: …

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How the brain integrate recent experiences into existing memories ensures that memories contain the most recently available information?

Zaki, Y., Pennington, Z.T., Morales-Rodriguez, D. et al. Offline ensemble co-reactivation links memories across days. Nature (2024). https://doi.org/10.1038/s41586-024-08168-4

Abstract
“Memories are encoded in neural ensembles during learning1,2,3,4,5,6 and are stabilized by post-learning reactivation7,8,9,10,11,12,13,14,15,16,17. Integrating recent experiences into existing memories

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How memory and language are linked at the single-cell level?

D. E. Dijksterhuis et al. ,Pronouns reactivate conceptual representations in human hippocampal neurons.Science 385,1478-1484(2024).DOI:10.1126/science.adr2813

Abstract
“During discourse comprehension, every new word adds to an evolving representation of meaning that accumulates over consecutive sentences and constrains the next words

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How shifts in the composition of memory-encoding neuronal ensembles influence the evolution of a memory over time?

Vilde A. Kveim et al. ,Divergent recruitment of developmentally defined neuronal ensembles supports memory dynamics.Science 385,eadk0997(2024).DOI:10.1126/science.adk0997

Editor’s summary
Memories are not fixed; they evolve after encoding and their content can be updated upon changes in external or

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How the hippocampus supports episodic and spatial memory at the same time?

Alexander Nitsch, Naomi de Haas, Mona M. Garvert, Christian F. Doeller. Integrating episodic and spatial context signals in the hippocampus. bioRxiv 2024.06.24.600445; doi: https://doi.org/10.1101/2024.06.24.600445

Abstract
Episodic and spatial memory are the two key components of the mnemonic system

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How to build a bio-inspired hardware implementation of an analog spike-based hippocampus memory model?

Daniel Casanueva-Morato, Alvaro Ayuso-Martinez, Giacomo Indiveri, J P Dominguez-Morales,Gabriel Jimenez-Moreno. A bio-inspired hardware implementation of an analog spike-based hippocampus memory model. TechRxiv. April 03, 2024. DOI: 10.36227/techrxiv.171216721.14143739/v1

Abstract
“The need for processing at the edge the increasing amount of …

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How does the brain select what to remember during sleep?

Wannan Yang, Chen Sun, Roman Huszár, Thomas Hainmueller, Kirill Kiselev, György Buzsáki. “Selection of experience for memory by hippocampal sharp wave ripple.” Science 383, 1478-1483 (2024).

Abstract
Experiences need to be tagged during learning for further

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How hippocampal activity encodes numerous memories of specific events in life?

Selmaan N. Chettih,Emily L. Mackevicius,Stephanie Hale,Dmitriy Aronov. Barcoding of episodic memories in the hippocampus of a food-caching bird. Cell, March 29, 2024.  DOI:https://doi.org/10.1016/j.cell.2024.02.032

Summary
The hippocampus is critical for episodic memory. Although hippocampal activity represents place and …

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Whether associative memory involves temporally correlated spiking of medial temporal lobe (MTL) neurons that exhibit stimulus-specific tuning?

Kunz, L., Staresina, B.P., Reinacher, P.C. et al. Ripple-locked coactivity of stimulus-specific neurons and human associative memory. Nat Neurosci (2024). https://doi.org/10.1038/s41593-023-01550-x

Abstract
“Associative memory enables the encoding and retrieval of relations between different stimuli. To better understand its neural …

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How to build a dynamic attractor network model of memory formation, reinforcement and forgetting?

Marta Boscaglia, Chiara Gastaldi, Wulfram Gerstner, Rodrigo Quian Quiroga. A dynamic attractor network model of memory formation, reinforcement and forgetting. bioRxiv 2023.12.01.569560; doi: https://doi.org/10.1101/2023.12.01.569560

Abstract
“Empirical evidence shows that memories that are frequently revisited are easy to recall, …

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What are the mechanisms of memory storage and retrieval in hippocampal area CA3?

Yiding Li, John J. Briguglio, Sandro Romani, Jeffrey C. Magee. Mechanisms of memory storage and retrieval in hippocampal area CA3. bioRxiv 2023.05.30.542781; doi: https://doi.org/10.1101/2023.05.30.542781

Abstract
“Hippocampal area CA3 is thought to play a central role in memory formation and …

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