Yanjun Sun, Daniel T. Pederick, Xiangmin Xu, Liqun Luo, Lisa M. Giocomo. Topographic CA1 input shapes subicular spatial coding. bioRxiv 2026.03.24.714092; doi: https://doi.org/10.64898/2026.03.24.714092

Abstract
“Topographic organization characterizes hippocampal circuits, yet its functional significance remains unclear. By selectively disrupting CA1-to-subiculum topographic projections in latrophilin-2 conditional knockout mice, we show that precise topography shapes the anatomical distribution of subicular spatial coding while preserving single-cell tuning. Disrupted topography also selectively impairs boundary vector coding and long-term network stability. Thus, CA1 inputs provide an indispensable scaffold for organizing subicular spatial maps and dynamics.”

Yanjun Sun, Daniel T. Pederick, Xiangmin Xu, Liqun Luo, Lisa M. Giocomo. Topographic CA1 input shapes subicular spatial coding. bioRxiv 2026.03.24.714092; doi: https://doi.org/10.64898/2026.03.24.714092