How does one brain circuit encode memories of both places and events?
Sarthak Chandra, Sugandha Sharma, Rishidev Chaudhuri & Ila Fiete. Episodic and associative memory from spatial scaffolds in the hippocampus. Nature (2025). https://doi.org/10.1038/s41586-024-08392-y
Abstract
“Hippocampal circuits in the brain enable two distinct cognitive functions: the construction of spatial maps for …
How sleep microstructure organizes memory replay?
Hongyu Chang, Wenbo Tang, Annabella M. Wulf, Thokozile Nyasulu, Madison E. Wolf, Antonio Fernandez-Ruiz & Azahara Oliva. Sleep microstructure organizes memory replay. Nature (2025). https://doi.org/10.1038/s41586-024-08340-w
Abstract
“Recently acquired memories are reactivated in the hippocampus during sleep, an initial step …
How to understand the neural basis of natural intelligence?
Angelo Forli, Michael M. Yartsev. Understanding the neural basis of natural intelligence. Cell, 2024, Volume 187, Issue 21, 5833 – 5837
Abstract
“Understanding the neural basis of natural intelligence necessitates a paradigm shift: from strict reductionism toward …
How synaptic plasticity underlies place-field formation and memory encoding during navigation?
Gonzalez, K.C., Negrean, A., Liao, Z. et al. Synaptic basis of feature selectivity in hippocampal neurons. Nature (2024). https://doi.org/10.1038/s41586-024-08325-9
Abstract
“A central question in neuroscience is how synaptic plasticity shapes the feature selectivity of neurons in behaving animals1. …
How human hippocampal CA3 uses specific functional connectivity rules for efficient associative memory?
Jake F. Watson, Victor Vargas-Barroso, Rebecca J. Morse-Mora, Andrea Navas-Olive, Mojtaba R. Tavakoli, Johann G. Danzl, Matthias Tomschik, Karl Rössler, Peter Jonas. Human hippocampal CA3 uses specific functional connectivity rules for efficient associative memory. Cell, 2024. DOI: 10.1016/j.cell.2024.11.022
Summary…
How are associative memories formed? Which cells represent a memory, and when are they engaged?
Clément Pouget, Flora Morier, Nadja Treiber, Pablo Fernández García, Nina Mazza, Run Zhang, Isaiah Reeves, Stephen Winston, Mark A. Brimble, Christina K. Kim, Gisella Vetere. Deconstruction of a memory engram reveals distinct ensembles recruited at learning. bioRxiv 2024.12.11.627894; doi: …
How grid cell firing patterns rapidly adapt to novel or changing environmental features on a timescale relevant to behaviour?
Wen, J.H., Sorscher, B., Aery Jones, E.A. et al. One-shot entorhinal maps enable flexible navigation in novel environments. Nature (2024). https://doi.org/10.1038/s41586-024-08034-3
Abstract
“Animals must navigate changing environments to find food, shelter or mates. In mammals, grid cells in …
How the representations of space and time interact in the hippocampal memory system?
Chen, Shijie, Ning Cheng, Xiaojing Chen, and Cheng Wang. “Integration and competition between space and time in the hippocampus.” Neuron (2024).
Summary
“Episodic memory is organized in both spatial and temporal contexts. The hippocampus is crucial for episodic …
How the brain integrate recent experiences into existing memories ensures that memories contain the most recently available information?
Zaki, Y., Pennington, Z.T., Morales-Rodriguez, D. et al. Offline ensemble co-reactivation links memories across days. Nature (2024). https://doi.org/10.1038/s41586-024-08168-4
Abstract
“Memories are encoded in neural ensembles during learning1,2,3,4,5,6 and are stabilized by post-learning reactivation7,8,9,10,11,12,13,14,15,16,17. Integrating recent experiences into existing memories …
How learning-associated astrocyte ensembles regulate memory recall?
Williamson, M.R., Kwon, W., Woo, J. et al. Learning-associated astrocyte ensembles regulate memory recall. Nature (2024). https://doi.org/10.1038/s41586-024-08170-w
Abstract
“The physical manifestations of memory formation and recall are fundamental questions that remain unresolved1. At the cellular level, ensembles …
How bats use environmental acoustic information to perform acoustic cognitive map–based navigation?
Aya Goldshtein, Xing Chen, Eran Amichai, Arjan Boonman, Lee Harten, Omer Yinon,Yotam Orchan, Ran Nathan, Sivan Toledo, Iain D. Couzin, Yossi Yovel. Acoustic cognitive map–based navigation in echolocating bats.Science 386,561-567(2024).DOI:10.1126/science.adn6269
Editor’s summary
“Insectivorous bats are well known to use …
Where visual objects are encoded in the mouse brain or how visual objects impact processing within the spatial navigation system?
Dominique Siegenthaler, Henry Denny, Sofía Skromne Carrasco, Johanna Luise Mayer, Adrien Peyrache, Stuart Trenholm, Émilie Macé. Visual objects refine head direction coding. bioRxiv 2024.10.21.619417; doi: https://doi.org/10.1101/2024.10.21.619417
Abstract
“Animals use visual objects to guide navigation-related behaviors, from hunting prey, …
What are the mechanisms of memory-supporting neuronal dynamics in hippocampal area CA3?
Li, Yiding, John J. Briguglio, Sandro Romani, Jeffrey C. Magee, Eddy Kinganda-Lusamaki, Adrienne Amuri-Aziza, Nicolas Fernandez-Nuñez et al. “Mechanisms of memory-supporting neuronal dynamics in hippocampal area CA3.” Cell 187 (2024): 2030-2051.
Summary
“Hippocampal CA3 is central to …
How memory and language are linked at the single-cell level?
D. E. Dijksterhuis et al. ,Pronouns reactivate conceptual representations in human hippocampal neurons.Science 385,1478-1484(2024).DOI:10.1126/science.adr2813
Abstract
“During discourse comprehension, every new word adds to an evolving representation of meaning that accumulates over consecutive sentences and constrains the next words…
How zebrafish place cells integrate multiple sources of information and flexibly remap to form distinct spatial maps?
Yang, C., Mammen, L., Kim, B. et al. A population code for spatial representation in the zebrafish telencephalon. Nature (2024). https://doi.org/10.1038/s41586-024-07867-2
Abstract
“Spatial learning in teleost fish requires an intact telencephalon1, a brain region that contains putative analogues to …
How hippocampal neuronal activity is aligned with action plans?
Ipshita Zutshi, Athina Apostolelli, Wannan Yang, Zheyang Zheng, Tora Dohi, Edoardo Balzani, Alex Williams, Cristina Savin, Gyorgy Buzsaki. Hippocampal neuronal activity is aligned with action plans. bioRxiv 2024.09.05.611533; doi: https://doi.org/10.1101/2024.09.05.611533
Abstract
“Neurons in the hippocampus are correlated with …
How ants use latent learning without map-like representation of space to navigate?
Leo Clement, Sebastian Schwarz, Antoine Wystrach. Latent learning without map-like representation of space in navigating ants. bioRxiv 2024.08.29.610243; doi: https://doi.org/10.1101/2024.08.29.610243
Abstract
“Desert ants are excellent navigators. Each individual learns long foraging routes meandering between the trees and bushes in …
How shifts in the composition of memory-encoding neuronal ensembles influence the evolution of a memory over time?
Vilde A. Kveim et al. ,Divergent recruitment of developmentally defined neuronal ensembles supports memory dynamics.Science 385,eadk0997(2024).DOI:10.1126/science.adk0997
Editor’s summary
“Memories are not fixed; they evolve after encoding and their content can be updated upon changes in external or …
Whether the entorhinal grid system is also involved in predicting where an animal will be in the next moment?
Ayako Ouchi, Shigeyoshi Fujisawa ,Predictive grid coding in the medial entorhinal cortex.Science 385,776-784(2024).DOI:10.1126/science.ado4166
Editor’s summary
“Grid cells in the entorhinal cortex create a coordinate system of the environment for spatial navigation. However, it is not clear whether …
What’s the relationship between world-centered (allocentric) and self-centered (egocentric) frames of spatial coding in the hippocampus during navigation?
Jordan Carpenter, Jan Sigurd Blackstad, David Tingley, Valentin A. Normand, Edvard I. Moser, May-Britt Moser, Benjamin A. Dunn. Investigating egocentric tuning in hippocampal CA1 neurons. Journal of Neuroscience, 13 August 2024, e0040242024; DOI: 10.1523/JNEUROSCI.0040-24.2024
Abstract
“Navigation requires integrating …
How abstract representations are encoded in populations of hippocampal neurons, how they emerge through learning and how they relate to behaviour?
Courellis, H.S., Minxha, J., Cardenas, A.R. et al. Abstract representations emerge in human hippocampal neurons during inference. Nature (2024). https://doi.org/10.1038/s41586-024-07799-x
Abstract
“Humans have the remarkable cognitive capacity to rapidly adapt to changing environments. Central to this capacity …
How the brain merge information from across sensory modalities?
Daniel D Kato, Randy M Bruno. Stability of cross-sensory input to primary somatosensory cortex across experience. bioRxiv 2024.08.07.607026; doi: https://doi.org/10.1101/2024.08.07.607026
Abstract
“Merging information from across sensory modalities is key to forming robust, disambiguated percepts of the world, …
How the hippocampus supports episodic and spatial memory at the same time?
Alexander Nitsch, Naomi de Haas, Mona M. Garvert, Christian F. Doeller. Integrating episodic and spatial context signals in the hippocampus. bioRxiv 2024.06.24.600445; doi: https://doi.org/10.1101/2024.06.24.600445
Abstract
“Episodic and spatial memory are the two key components of the mnemonic system …
How the human brain to maintain a sense of direction during naturalistic, dynamic navigation?
Zhengang Lu, Joshua B. Julian, Geoffrey K. Aguirre, Russell A. Epstein. Neural compass in the human brain during naturalistic virtual navigation. bioRxiv 2024.04.18.590112; doi: https://doi.org/10.1101/2024.04.18.590112
SUMMARY
“Humans and animals maintain a consistent representation of their facing direction during spatial …
How bees achieve vertebrate-like, high-level navigation behaviors with far fewer neurons in their brains?
Patel RN, Roberts NS, Kempenaers J, Zadel A, Heinze S. Parallel vector memories in the brain of a bee as foundation for flexible navigation. Proceedings of the National Academy of Sciences. 2024 Jul 23;121(30):e2402509121.
Significance
“Insects navigate by …
How to brain to implemnt control and recalibration of path integration in place cells using optic flow?
Madhav, M.S., Jayakumar, R.P., Li, B.Y. et al. Control and recalibration of path integration in place cells using optic flow. Nat Neurosci 27, 1599–1608 (2024). https://doi.org/10.1038/s41593-024-01681-9
Abstract
“Hippocampal place cells are influenced by both self-motion (idiothetic) signals and external …
How visual information becomes encoded by the brain’s navigation systems?
Dubanet, O. and Higley, M.J., 2024. Retrosplenial inputs drive visual representations in the medial entorhinal cortex. Cell Reports, 43(7).
Summary
“The importance of visual cues for navigation and goal-directed behavior is well established, although the neural mechanisms supporting …
How neural population dynamics flexibly adapt during different behavioural states to govern the speed and stability of sensory encoding？
Horrocks, E.A.B., Rodrigues, F.R. & Saleem, A.B. Flexible neural population dynamics govern the speed and stability of sensory encoding in mouse visual cortex. Nat Commun 15, 6415 (2024). https://doi.org/10.1038/s41467-024-50563-y
Abstract
“Time courses of neural responses underlie real-time sensory processing …
How hippocampal-entorhinal cognitive maps and cortical motor system represent action plans and their outcomes?
Irina Barnaveli, Simone Viganò, Daniel Reznik, Patrick Haggard, Christian F. Doeller. Hippocampal-entorhinal cognitive maps and cortical motor system represent action plans and their outcomes. bioRxiv 2024.07.04.602119; doi: https://doi.org/10.1101/2024.07.04.602119
“Efficiently interacting with the environment requires weighing and selecting among …
How retrosplenial inputs drive visual representations in the medial entorhinal cortex?
Dubanet, Olivier, and Michael J. Higley. “Retrosplenial inputs drive visual representations in the medial entorhinal cortex.” Cell Reports 43.7 (2024).
Summary
“The importance of visual cues for navigation and goal-directed behavior is well established, although the neural mechanisms …
Whether and how neural dynamics of hippocampal neurons are influenced by the presence and actions of human experimenters？
Snyder, M.C., Qi, K.K. & Yartsev, M.M. Neural representation of human experimenters in the bat hippocampus. Nat Neurosci (2024). https://doi.org/10.1038/s41593-024-01690-8
Abstract
“Here we conducted wireless electrophysiological recording of hippocampal neurons from Egyptian fruit bats in the presence of human …
How the brain perform control and recalibration of path integration in place cells using optic flow?
Madhav, M.S., Jayakumar, R.P., Li, B.Y. et al. Control and recalibration of path integration in place cells using optic flow. Nat Neurosci (2024). https://doi.org/10.1038/s41593-024-01681-9
Abstract
“Hippocampal place cells are influenced by both self-motion (idiothetic) signals and external sensory …
What’s the human neural dynamics of real-world and imagined navigation?
Martin Seeber, Matthias Stangl, Mauricio Vallejo, Uros Topalovic, Sonja Hiller, Casey H. Halpern, Jean-Philippe Langevin, Vikram R. Rao, Itzhak Fried, Dawn Eliashiv, Nanthia Suthana. Human neural dynamics of real-world and imagined navigation. bioRxiv 2024.05.23.595237; doi: https://doi.org/10.1101/2024.05.23.595237
Summary
“The …
How medial entorhinal cortex mediates learning of context-dependent interval timing behavior?
Bigus, E.R., Lee, HW., Bowler, J.C. et al. Medial entorhinal cortex mediates learning of context-dependent interval timing behavior. Nat Neurosci (2024). https://doi.org/10.1038/s41593-024-01683-7
Abstract
“Episodic memory requires encoding the temporal structure of experience and relies on brain circuits in …
How animals simultaneously map their surroundings and tether goals to these surroundings during early experience in a novel environment?
Dan, Chuntao, Brad K. Hulse, Ramya Kappagantula, Vivek Jayaraman and Ann M. Hermundstad. “A neural circuit architecture for rapid learning in goal-directed navigation.” Neuron (2024): DOI:https://doi.org/10.1016/j.neuron.2024.04.036
Summary
“Anchoring goals to spatial representations enables flexible navigation but is …
How the primate entorhinal cortex support mental navigation?
Neupane, S., Fiete, I. & Jazayeri, M. Mental navigation in the primate entorhinal cortex. Nature (2024). https://doi.org/10.1038/s41586-024-07557-z
Abstract
“A cognitive map is a suitably structured representation that enables novel computations using previous experience; for example, planning a …
How existing motor memories are maintained as new motor skills are continuously acquired?
Jae-Hyun Kim, Kayvon Daie, Nuo Li. A combinatorial neural code for long-term motor memory. bioRxiv 2024.06.05.597627; doi: https://doi.org/10.1101/2024.06.05.597627
Abstract
“Motor skill repertoire can be stably retained over long periods, but the neural mechanism underlying stable memory storage remains …
What’s the mechanism of spatial periodic computation of hippocampus-entorhinal circuit in navigation?
Bo Zhang, Jia Liu. The spatial periodic computation of hippocampus-entorhinal circuit in navigation. bioRxiv 2022.01.29.478346; doi: https://doi.org/10.1101/2022.01.29.478346
Summary
“To achieve the computational goal of navigating in both physical and mental spaces, human brain employs a cognitive map constructed by …
What’s the mechanisms and function of grid cells in cognition?
Ling L. Dong, and Ila R. Fiete. Grid Cells in Cognition: Mechanisms and Function. Annual Review of Neuroscience, 2024. 47:345–68.
Abstract
“The activity patterns of grid cells form distinctively regular triangular lattices over the explored spatial environment and are …
How the hippocampus represents different spaces?
Fenton, A.A. Remapping revisited: how the hippocampus represents different spaces. Nat. Rev. Neurosci. (2024). https://doi.org/10.1038/s41583-024-00817-x
Abstract
“The representation of distinct spaces by hippocampal place cells has been linked to changes in their place fields (the locations in the …
How to build a bio-inspired hardware implementation of an analog spike-based hippocampus memory model?
Daniel Casanueva-Morato, Alvaro Ayuso-Martinez, Giacomo Indiveri, J P Dominguez-Morales,Gabriel Jimenez-Moreno. A bio-inspired hardware implementation of an analog spike-based hippocampus memory model. TechRxiv. April 03, 2024. DOI: 10.36227/techrxiv.171216721.14143739/v1
Abstract
“The need for processing at the edge the increasing amount of …
How does the brain select what to remember during sleep?
Wannan Yang, Chen Sun, Roman Huszár, Thomas Hainmueller, Kirill Kiselev, György Buzsáki. “Selection of experience for memory by hippocampal sharp wave ripple.” Science 383, 1478-1483 (2024).
Abstract
“Experiences need to be tagged during learning for further …
How hippocampal activity encodes numerous memories of specific events in life?
Selmaan N. Chettih,Emily L. Mackevicius,Stephanie Hale,Dmitriy Aronov. Barcoding of episodic memories in the hippocampus of a food-caching bird. Cell, March 29, 2024. DOI:https://doi.org/10.1016/j.cell.2024.02.032
Summary
“The hippocampus is critical for episodic memory. Although hippocampal activity represents place and …
How egocentric coding properties arise from its presynaptic inputs, and how egocentric cells represent items across different behavioral contexts?
Cheng, Ning, Qiqi Dong, Zhen Zhang, Li Wang, Xiaojing Chen, and Cheng Wang. “Egocentric processing of items in spines, dendrites, and somas in the retrosplenial cortex.” Neuron (2023).
Summary
“Egocentric representations of external items are essential for spatial …
How the medial entorhinal cortex develops during learning and influences memory?
Malone, T.J., Tien, NW., Ma, Y. et al. A consistent map in the medial entorhinal cortex supports spatial memory. Nat Commun 15, 1457 (2024). https://doi.org/10.1038/s41467-024-45853-4
Abstract
“The medial entorhinal cortex (MEC) is hypothesized to function as a …
How place cells use environmental cues to resolve the ambiguity of arotationally symmetric environment?
Cheng, Han Yin, Dorothy W. Overington, and Kate J. Jeffery. “A configural context signal simultaneously but separably drives positioning and orientation of hippocampal place fields.” Hippocampus 34.2 (2024): 73-87.
Abstract
“Effective self-localization requires that the brain can …
Whether associative memory involves temporally correlated spiking of medial temporal lobe (MTL) neurons that exhibit stimulus-specific tuning?
Kunz, L., Staresina, B.P., Reinacher, P.C. et al. Ripple-locked coactivity of stimulus-specific neurons and human associative memory. Nat Neurosci (2024). https://doi.org/10.1038/s41593-023-01550-x
Abstract
“Associative memory enables the encoding and retrieval of relations between different stimuli. To better understand its neural …
How to convert an allocentric goal into an egocentric steering signal?
Mussells Pires, P., Zhang, L., Parache, V. et al. Converting an allocentric goal into an egocentric steering signal. Nature (2024). https://doi.org/10.1038/s41586-023-07006-3
Abstract
“Neuronal signals that are relevant for spatial navigation have been described in many species1,2,3,4,5,6,7,8,9,10. However, a circuit-level …
Whether the entorhinal cortex integrates relational information about changing values during prospective decision making using a grid-like representation of an abstract value space?
Nitsch, A., Garvert, M.M., Bellmund, J.L.S. et al. Grid-like entorhinal representation of an abstract value space during prospective decision making. Nat Commun 15, 1198 (2024). https://doi.org/10.1038/s41467-024-45127-z
Abstract
“How valuable a choice option is often changes over time, …
How subfield-specific interneuron circuits govern the hippocampal response to novelty in male mice
Hainmueller, T., Cazala, A., Huang, LW. et al. Subfield-specific interneuron circuits govern the hippocampal response to novelty in male mice. Nat Commun 15, 714 (2024). https://doi.org/10.1038/s41467-024-44882-3
Abstract
“The hippocampus is the brain’s center for episodic memories. Its subregions, the …
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Brain Inspired Navigation Blog
New discovery worth spreading on brain-inspired navigation in neurorobotics and neuroscience
Recent Posts
- How does one brain circuit encode memories of both places and events?
- How sleep microstructure organizes memory replay?
- How to understand the neural basis of natural intelligence?
- How synaptic plasticity underlies place-field formation and memory encoding during navigation?
- How human hippocampal CA3 uses specific functional connectivity rules for efficient associative memory?
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