Sehgal, M., Filho, D.A., Kastellakis, G. et al. Compartmentalized dendritic plasticity in the mouse retrosplenial cortex links contextual memories formed close in time. Nat Neurosci (2025). https://doi.org/10.1038/s41593-025-01876-8

Abstract
“Events occurring close in time are often linked in memory, and recent studies suggest that such memories are encoded by overlapping neuronal ensembles. However, the role of dendritic plasticity mechanisms in linking memories is unknown. Here we show that memory linking is dependent not only on neuronal ensemble overlap in the mouse retrosplenial cortex, but also on branch-specific dendritic allocation mechanisms. The same dendritic segments are preferentially activated by two linked (but not independent) contextual memories, and spine clusters added after each of two linked (but not independent) contextual memories are allocated to the same dendritic segments. Importantly, we show that the reactivation of dendrites activated during the first context exploration is sufficient to link two contextual memories. Our results demonstrate a critical role for localized dendritic plasticity in memory integration and reveal rules governing how linked and independent memories are allocated to dendritic compartments.”

Sehgal, M., Filho, D.A., Kastellakis, G. et al. Compartmentalized dendritic plasticity in the mouse retrosplenial cortex links contextual memories formed close in time. Nat Neurosci (2025). https://doi.org/10.1038/s41593-025-01876-8